Drug Class: HMG-CoA Reductase Inhibitor + Cholesterol Absorption Inhibitor — Combination Lipid-Lowering Therapy | Form: Tablets (Oral) | Prescription Status: Prescription Only (Rx) — DRAP Registered
What is Rolip Eze Tablets 5mg+10mg?
Rolip Eze 5mg+10mg is a fixed-dose combination tablet containing Rosuvastatin 5mg and Ezetimibe 10mg — two complementary cholesterol-lowering medicines working through two entirely different mechanisms to provide more effective LDL reduction (خراب کولیسٹرول میں کمی) than either medicine can achieve alone. Rosuvastatin 5mg is the lowest-strength statin component — blocking cholesterol production in the liver (جگر میں کولیسٹرول بننا بند کرتا ہے). Ezetimibe 10mg blocks cholesterol absorption in the small intestine (چھوٹی آنت میں کولیسٹرول جذب ہونا بند کرتا ہے). Together they typically achieve LDL reductions of 45 to 55% — significantly greater than either medicine alone — while keeping the statin dose at its lowest available level. This makes Rolip Eze 5mg+10mg the most appropriate combination strength for patients who need dual-action cholesterol lowering but require a gentle starting dose — including elderly patients, patients of Asian origin, those with mild kidney impairment, and patients who have experienced muscle side effects at higher statin doses. It requires a valid prescription and is always used alongside a healthy diet and lifestyle changes.
What is Rolip Eze 5mg+10mg Used For?
Rolip Eze 5mg+10mg is indicated for the following conditions:
Primary Hypercholesterolaemia — Statin-Sensitive Patients (کولیسٹرول کی زیادتی — حساس مریض) — elevated LDL cholesterol requiring dual-action lowering in patients who need the most cautious starting dose — including elderly patients (بزرگ مریض), patients of Asian origin (ایشیائی مریض), and those with mild kidney impairment
Statin Intolerance — Muscle Sensitivity (اسٹیٹن سے پٹھوں کی تکلیف) — patients who have experienced muscle side effects (درد یا کمزوری) at standard or higher statin doses — the 5mg Rosuvastatin component is the lowest available statin dose, minimising muscle risk while Ezetimibe adds meaningful additional LDL lowering
Mixed Dyslipidaemia (خون میں چربی کی خرابی) — a combination of elevated LDL, elevated triglycerides, and low HDL — the dual mechanism addresses multiple lipid abnormalities simultaneously at a tolerable statin dose
Prevention of Cardiovascular Events — Moderate Risk (دل کی بیماری سے بچاؤ — اعتدال پسند خطرہ) — reducing cardiovascular risk in patients who require cholesterol lowering but for whom higher statin doses are not appropriate at the outset
Combination Therapy — Gentle Initiation (مشترکہ علاج — آہستہ شروعات) — used when the treating doctor wishes to initiate dual-mechanism lipid lowering from the start without exposing the patient to a higher statin dose during the initial treatment phase
How Does Rolip Eze 5mg+10mg Work?
Rolip Eze 5mg+10mg combines two medicines that lower cholesterol through two entirely different and complementary pathways.
Rosuvastatin 5mg — Hepatic Cholesterol Production Blockade: Rosuvastatin inhibits HMG-CoA reductase (HMG-CoA ریڈکٹیز انزائم) — the key enzyme the liver uses to synthesise cholesterol. When internal cholesterol production falls, the liver upregulates LDL receptors (LDL ریسیپٹرز) on its surface — pulling LDL particles from the bloodstream into the liver for processing and elimination. At 5mg — the lowest available Rosuvastatin dose — this effect is clinically meaningful while being the gentlest option on muscle tissue and kidneys.
Ezetimibe 10mg — Intestinal Cholesterol Absorption Blockade: Ezetimibe selectively inhibits the NPC1L1 transporter protein (این پی سی 1 ایل 1 پروٹین) in the intestinal wall — the primary channel through which dietary cholesterol and bile-derived cholesterol are absorbed back into the body. By blocking this transporter, Ezetimibe reduces cholesterol delivery from the intestine to the liver by approximately 50% — prompting further LDL receptor upregulation and additional LDL clearance from the circulation.
The Advantage of Combining at the Lowest Statin Dose: By pairing the minimum effective statin dose with Ezetimibe, Rolip Eze 5mg+10mg achieves combined LDL reductions of approximately 45 to 55% — substantially more than Rosuvastatin 5mg alone (approximately 38–45%) — while maintaining the safety and tolerability profile of the lowest statin dose. This approach is particularly valuable for patients where tolerability is the primary concern but meaningful cholesterol lowering is still clinically necessary.
Dosage and Administration
Rolip Eze 5mg+10mg must be taken exactly as prescribed by your doctor. Do not change your dose without medical advice (ڈاکٹر کے مشورے کے بغیر خوراک تبدیل نہ کریں).
| Indication | Dose | Notes |
|---|---|---|
| Primary hypercholesterolaemia — sensitive patients (حساس مریض) | One tablet once daily | Lowest statin dose — monitor response at 4 to 8 weeks |
| Statin intolerance — muscle sensitivity (پٹھوں کی تکلیف) | One tablet once daily | Minimises statin exposure while maintaining dual LDL lowering |
| Elderly patients (بزرگ مریض) | One tablet once daily | Preferred low-dose starting option |
| Asian patients (ایشیائی مریض) | One tablet once daily — start here | Higher Rosuvastatin blood levels in Asian populations — 5mg is recommended |
| Cardiovascular prevention — moderate risk | One tablet once daily | Titrate to higher strength if LDL target not achieved |
Important Administration Instructions:
- Swallow the tablet whole with a glass of water (پانی کے ساتھ پوری گولی نگلیں)
- Can be taken at any time of day — with or without food — take at the same time each day
- Do not take within 2 hours of antacids containing aluminium or magnesium — reduces Ezetimibe absorption
- Continue a healthy diet low in saturated fat and cholesterol alongside this medicine (صحت مند غذا جاری رکھیں)
- Cholesterol levels are typically rechecked after 4 to 8 weeks to assess response and guide any dose escalation
- If you miss a dose (خوراک بھول جائیں) — take it as soon as you remember. If it is almost time for the next dose, skip the missed one. Never take a double dose.
Active Ingredients
| Ingredient | Dose | Role |
|---|---|---|
| Rosuvastatin | 5mg | HMG-CoA reductase inhibitor — lowest available statin dose — blocks hepatic cholesterol synthesis and upregulates LDL receptor clearance |
| Ezetimibe | 10mg | Cholesterol absorption inhibitor — blocks NPC1L1 transporter in the small intestine, reducing dietary and biliary cholesterol absorption by approximately 50% |
Also contains standard tablet excipients. Please check the product label or ask your pharmacist for full composition details.
Who Should NOT Use Rolip Eze 5mg+10mg?
Do not use Rolip Eze if you (استعمال نہ کریں اگر):
- Are allergic to Rosuvastatin, Ezetimibe, or any other ingredient in the tablet (الرجی ہو)
- Have active liver disease or persistently elevated liver enzymes (جگر کی بیماری)
- Are pregnant (حاملہ) — statins are absolutely contraindicated in pregnancy — stop immediately if pregnancy occurs
- Are breastfeeding (دودھ پلانے والی ماں)
- Are taking Cyclosporine (سائکلوسپورین) — significantly increases Rosuvastatin levels even at 5mg
Tell your doctor before use if (ڈاکٹر کو بتائیں اگر):
- You have kidney or liver problems (گردے یا جگر کی بیماری) — the 5mg Rosuvastatin dose is specifically preferred in kidney impairment
- You have a personal or family history of muscle disease (پٹھوں کی بیماری)
- You have hypothyroidism (تھائرائیڈ کی کمی) — increases muscle side effect risk with statins
- You drink alcohol regularly (شراب پیتے ہوں) — increases liver damage risk
- You are of Asian origin (ایشیائی نسل) — higher Rosuvastatin blood levels make 5mg the recommended starting dose
- You are planning to become pregnant — statins must be stopped before conception
- You have gallbladder disease (پتہ کی بیماری) — Ezetimibe is not recommended in active gallbladder conditions
Side Effects
Not everyone will experience side effects. Rolip Eze 5mg+10mg carries the lowest statin-related side effect risk in the Rolip Eze range due to the minimum statin dose.
Common Side Effects (عام ضمنی اثرات):
- Headache (سردرد)
- Nausea (متلی) and abdominal discomfort (پیٹ کی تکلیف)
- Muscle aches (پٹھوں میں درد) — least likely at 5mg Rosuvastatin — but report any persistent muscle pain to your doctor
- Dizziness (چکر آنا)
- Constipation (قبض) or diarrhoea (اسہال)
- Fatigue (تھکاوٹ)
- New-onset diabetes risk (ذیابیطس) — lowest statin dose minimises but does not eliminate this risk — blood sugar monitoring is recommended
Serious Side Effects (سنگین ضمنی اثرات — stop the medicine and seek medical help):
- Myopathy and Rhabdomyolysis (پٹھوں کی شدید تکلیف اور ٹوٹنا) — severe unexplained muscle pain, weakness, or tenderness with dark or cola-coloured urine (پیشاب کا رنگ گہرا ہونا) — risk is lowest at 5mg statin dose but not zero — stop immediately and seek urgent medical attention
- Liver damage (جگر کو نقصان) — yellowing of skin or eyes (یرقان), dark urine, severe fatigue — stop and consult doctor immediately
- Pancreatitis (لبلبے کی سوزش) — severe upper abdominal pain radiating to the back — rare with Ezetimibe — seek immediate medical attention
- Severe allergic reaction (شدید الرجی) — facial swelling, difficulty breathing — seek emergency help immediately
Stop the medicine and contact your doctor immediately if any serious side effect occurs (فوری طور پر ڈاکٹر سے رابطہ کریں).
Drug Interactions
Always inform your doctor and pharmacist about all medicines you are currently taking (تمام ادویات کے بارے میں ڈاکٹر کو بتائیں).
| Medicine / Substance | Effect of Interaction |
|---|---|
| Cyclosporine (سائکلوسپورین) | Dramatically increases Rosuvastatin and Ezetimibe levels — contraindicated |
| Warfarin and anticoagulants (خون پتلا کرنے والی ادویات) | Rosuvastatin increases anticoagulant effect — monitor INR closely |
| Fibrates — e.g. Gemfibrozil (کولیسٹرول کی ادویات) | Increases myopathy risk and raises Ezetimibe levels — avoid Gemfibrozil — Fenofibrate with caution |
| Bile acid sequestrants — e.g. Cholestyramine | Reduces Ezetimibe absorption — take Rolip Eze at least 2 hours before or 4 hours after cholestyramine |
| Antacids containing aluminium and magnesium | Reduce Ezetimibe absorption — take Rolip Eze at least 2 hours before antacids |
| HIV protease inhibitors — e.g. Lopinavir, Ritonavir | Increase Rosuvastatin levels — use with caution even at 5mg — inform your doctor |
| Oral contraceptives (مانع حمل گولیاں) | Rosuvastatin may increase blood levels of some hormonal contraceptives — inform your doctor |
| Alcohol (شراب) | Increases liver damage risk — avoid excessive alcohol |
Storage Instructions
- Store below 25°C in a cool, dry place (ٹھنڈی اور خشک جگہ پر رکھیں)
- Keep away from direct sunlight and moisture (دھوپ اور نمی سے دور رکھیں)
- Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں)
- Do not use after the expiry date printed on the pack (میعاد ختم ہونے کے بعد استعمال نہ کریں)
- Store in the original packaging to protect from light
Frequently Asked Questions
What is Rolip Eze 5mg+10mg used for?
Rolip Eze 5mg+10mg combines Rosuvastatin 5mg and Ezetimibe 10mg to lower LDL cholesterol (خراب کولیسٹرول) through dual action — blocking both cholesterol production in the liver (جگر میں کولیسٹرول بننا بند کرتا ہے) and cholesterol absorption in the small intestine (چھوٹی آنت میں جذب ہونا بند کرتا ہے). Together they achieve approximately 45 to 55% LDL reduction — while keeping the statin dose at its lowest available level for maximum tolerability.
Who is Rolip Eze 5mg+10mg specifically designed for?
This lowest-dose combination is specifically designed for patients who need dual-action cholesterol lowering but require the most cautious statin dose — including elderly patients (بزرگ مریض), patients of Asian origin (ایشیائی مریض) who have higher Rosuvastatin blood levels at any given dose, patients with mild kidney impairment, and patients who have previously experienced muscle side effects at higher statin doses. It allows meaningful cholesterol lowering to be initiated safely in these sensitive patient groups.
How does Rolip Eze 5mg+10mg compare to the other Rolip Eze strengths?
The Rolip Eze range offers three combination strengths — 5mg+10mg, 10mg+10mg, and 10mg+20mg — with increasing LDL-lowering intensity. The 5mg+10mg provides the gentlest dual-action lowering (45–55% LDL reduction) and is suitable for the most sensitive patients. The 10mg+10mg provides standard-intensity dual therapy (60–70% LDL reduction) for most adults. The 10mg+20mg provides high-intensity dual therapy (65–72% LDL reduction) for highest-risk patients. Your doctor will prescribe the most appropriate strength based on your cholesterol level, cardiovascular risk, and individual tolerability.
Can I switch from Rolip Eze 5mg+10mg to a higher strength later?
Yes — if your cholesterol levels are rechecked after 4 to 8 weeks and the 5mg+10mg combination has not achieved your target LDL level, your doctor may step up to the Rolip Eze 10mg+10mg or 10mg+20mg combination. Dose escalation decisions are always based on your lipid response, tolerability, and cardiovascular risk assessment — never change strength independently (ڈاکٹر کے مشورے کے بغیر خوراک تبدیل نہ کریں).
Is Rolip Eze 5mg+10mg safe for patients with kidney problems?
The 5mg Rosuvastatin dose is the specifically recommended starting dose for patients with kidney impairment — as Rosuvastatin blood levels are higher in patients with reduced kidney function, increasing the risk of muscle side effects at standard doses. The Ezetimibe component does not require dose adjustment in kidney impairment. However, your doctor will assess your kidney function and determine whether this combination is appropriate for your individual situation.
⚕️ Medical Disclaimer: This product description is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Rolip Eze is a prescription combination medicine — always take it exactly as directed by your doctor. Stop immediately and seek urgent medical help if you develop severe muscle pain or dark urine. Women who are pregnant or planning pregnancy must not take this medicine. Regular cholesterol and liver monitoring is essential during treatment.
DRAP Registered | Prescription Only (Rx) | For oral use only | Keep out of reach of children