Drug Class: HMG-CoA Reductase Inhibitor + Cholesterol Absorption Inhibitor — High-Intensity Combination Lipid-Lowering Therapy | Form: Tablets (Oral) | Prescription Status: Prescription Only (Rx) — DRAP Registered
What is Rolip Eze Tablets 10mg+20mg?
Rolip Eze 10mg+20mg is a high-intensity fixed-dose combination tablet containing Ezetimibe 10mg and Rosuvastatin 20mg — two complementary cholesterol-lowering medicines working through distinct mechanisms to achieve more powerful LDL reduction (خراب کولیسٹرول میں کمی) than either medicine can provide alone. Rosuvastatin 20mg is a high-intensity statin that blocks the liver's cholesterol production — at this dose it is classified as high-intensity statin therapy, typically achieving 55 to 60% LDL reduction on its own. Ezetimibe 10mg adds a further 15 to 20% LDL reduction by blocking cholesterol absorption in the small intestine (چھوٹی آنت میں کولیسٹرول جذب ہونا بند کرتا ہے). Together, Rolip Eze 10mg+20mg achieves LDL reductions of approximately 65 to 72% — among the most powerful non-injectable cholesterol-lowering options available. This combination is specifically prescribed for patients with the highest cardiovascular risk — including those with established heart disease, very high familial cholesterol, or those who have not reached aggressive LDL targets on standard statin therapy. It requires a valid prescription and is always used alongside a healthy diet and lifestyle changes.
What is Rolip Eze 10mg+20mg Used For?
Rolip Eze 10mg+20mg is indicated for the following conditions:
Established Cardiovascular Disease — High-Risk Patients (دل کی بیماری — زیادہ خطرہ) — patients with a history of heart attack (دل کا دورہ), coronary artery disease, angina, peripheral artery disease, or stroke who require maximum oral LDL lowering to prevent recurrent cardiovascular events
Familial Hypercholesterolaemia (موروثی کولیسٹرول کی زیادتی) — genetic condition causing severely elevated LDL levels — where even high-intensity statin monotherapy is often insufficient to reach the LDL targets required and combination therapy is clinically necessary from early in treatment
Primary Hypercholesterolaemia — Inadequately Controlled (ناکافی کنٹرول میں کولیسٹرول کی زیادتی) — elevated LDL not adequately controlled by Rosuvastatin 20mg alone — Ezetimibe provides substantial additional LDL reduction without increasing statin dose or statin-related side effects
Mixed Dyslipidaemia — Severe (خون میں چربی کی شدید خرابی) — significantly elevated LDL combined with high triglycerides and low HDL — requiring the dual mechanism of this combination to address multiple lipid abnormalities simultaneously
Statin Dose Limitation — Muscle Intolerance (پٹھوں کی تکلیف کی وجہ سے خوراک کی حد) — patients who cannot tolerate doses of Rosuvastatin above 20mg due to muscle side effects — Ezetimibe allows this maximum tolerated statin dose to be combined with additional LDL lowering without further increasing statin exposure
How Does Rolip Eze 10mg+20mg Work?
Rolip Eze 10mg+20mg combines two medicines that lower cholesterol through two entirely different and complementary pathways — producing synergistic LDL reduction significantly greater than the sum of their individual effects.
Rosuvastatin 20mg — High-Intensity Hepatic Cholesterol Blockade: Rosuvastatin is a fully synthetic, highly selective HMG-CoA reductase inhibitor — blocking the key enzyme (HMG-CoA ریڈکٹیز انزائم) that initiates cholesterol synthesis in the liver. By substantially reducing internal cholesterol production, Rosuvastatin forces the liver to upregulate LDL receptors (LDL ریسیپٹرز) — pulling LDL cholesterol from the bloodstream into the liver for processing. At 20mg — a high-intensity dose — Rosuvastatin typically achieves 55 to 60% LDL reduction on its own.
Ezetimibe 10mg — Intestinal Cholesterol Absorption Blockade: Ezetimibe selectively inhibits the NPC1L1 transporter protein (این پی سی 1 ایل 1 پروٹین) in the intestinal lining — the primary channel through which both dietary cholesterol and cholesterol secreted in bile are reabsorbed into the body. By blocking this transporter, Ezetimibe reduces cholesterol delivery from the intestine to the liver by approximately 50% — prompting the liver to further increase LDL receptor expression and clear more LDL from circulation.
Why the Combination at 10mg+20mg is More Powerful: When both routes of cholesterol supply are restricted simultaneously — production blocked by 20mg Rosuvastatin and absorption blocked by Ezetimibe — the liver's LDL receptor upregulation reaches its maximum potential. The result is a combined LDL reduction of approximately 65 to 72% — substantially greater than either agent alone. At this strength, Rolip Eze 10mg+20mg represents one of the most effective non-injectable lipid-lowering options available — appropriate for patients with the most demanding LDL targets.
Dosage and Administration
Rolip Eze 10mg+20mg must be taken exactly as prescribed by your doctor. Do not change your dose without medical advice (ڈاکٹر کے مشورے کے بغیر خوراک تبدیل نہ کریں).
| Indication | Dose | Notes |
|---|---|---|
| Established cardiovascular disease (دل کی بیماری) | One tablet once daily | Intensive LDL lowering — regular monitoring required |
| Familial hypercholesterolaemia (موروثی کولیسٹرول) | One tablet once daily | Specialist supervision — may require further optimisation |
| Primary hypercholesterolaemia — inadequately controlled | One tablet once daily | After demonstrating insufficient control on lower doses |
| Mixed dyslipidaemia — severe (شدید چربی کی خرابی) | One tablet once daily | Comprehensive lipid panel monitoring required |
Important Administration Instructions:
- Swallow the tablet whole with a glass of water (پانی کے ساتھ پوری گولی نگلیں)
- Can be taken at any time of day — with or without food — take at the same time each day
- Do not take within 2 hours of antacids containing aluminium or magnesium — reduces Ezetimibe absorption
- Continue a heart-healthy diet low in saturated fat alongside this medicine (صحت مند غذا جاری رکھیں)
- Cholesterol levels, liver enzymes, and kidney function are monitored after 4 to 8 weeks and periodically thereafter — given the high-intensity nature of this combination
- If you miss a dose (خوراک بھول جائیں) — take it as soon as you remember. If it is almost time for the next dose, skip the missed one. Never take a double dose.
Active Ingredients
| Ingredient | Dose | Role |
|---|---|---|
| Ezetimibe | 10mg | Cholesterol absorption inhibitor — blocks NPC1L1 transporter in the small intestine, reducing dietary and biliary cholesterol absorption by approximately 50% |
| Rosuvastatin | 20mg | High-intensity HMG-CoA reductase inhibitor — blocks hepatic cholesterol synthesis and maximises LDL receptor-mediated clearance from the bloodstream |
Also contains standard tablet excipients. Please check the product label or ask your pharmacist for full composition details.
Who Should NOT Use Rolip Eze 10mg+20mg?
Do not use Rolip Eze 10mg+20mg if you (استعمال نہ کریں اگر):
- Are allergic to Rosuvastatin, Ezetimibe, or any other ingredient in the tablet (الرجی ہو)
- Have active liver disease or persistently elevated liver enzymes (جگر کی بیماری)
- Are pregnant (حاملہ) — statins are absolutely contraindicated in pregnancy — stop immediately if pregnancy occurs and consult your doctor
- Are breastfeeding (دودھ پلانے والی ماں)
- Have moderate to severe kidney disease (گردے کی بیماری) — the 20mg Rosuvastatin component requires particularly careful assessment in renal impairment
- Are taking Cyclosporine (سائکلوسپورین) — significantly and dangerously increases Rosuvastatin blood levels — contraindicated
Tell your doctor before use if (ڈاکٹر کو بتائیں اگر):
- You have kidney or liver problems (گردے یا جگر کی بیماری) — essential assessment before using 20mg Rosuvastatin
- You have a personal or family history of muscle disease (پٹھوں کی بیماری) — muscle risk is greater at 20mg Rosuvastatin
- You have hypothyroidism (تھائرائیڈ کی کمی) — significantly increases muscle side effect risk with statins
- You drink alcohol regularly (شراب پیتے ہوں) — liver damage risk is greater at 20mg statin dose
- You are of Asian origin (ایشیائی نسل) — higher Rosuvastatin blood levels at 20mg require careful individual assessment
- You are planning to become pregnant — statins must be discontinued before conception
- You have gallbladder disease (پتہ کی بیماری) — Ezetimibe is not recommended in active gallbladder conditions
Side Effects
Not everyone will experience side effects. At this high-intensity combination dose, monitoring is particularly important throughout treatment.
Common Side Effects (عام ضمنی اثرات):
- Headache (سردرد)
- Nausea (متلی) and abdominal discomfort (پیٹ کی تکلیف)
- Muscle aches and weakness (پٹھوں میں درد اور کمزوری) — more likely at 20mg Rosuvastatin than at lower doses — report persistent muscle pain promptly
- Dizziness (چکر آنا)
- Constipation (قبض) or diarrhoea (اسہال)
- Fatigue (تھکاوٹ)
- New-onset or worsening diabetes (ذیابیطس) — statins modestly increase diabetes risk — blood sugar monitoring is recommended, particularly at 20mg
Serious Side Effects (سنگین ضمنی اثرات — stop the medicine and seek medical help):
- Myopathy and Rhabdomyolysis (پٹھوں کی شدید تکلیف اور ٹوٹنا) — severe unexplained muscle pain, weakness, or tenderness — especially with dark or cola-coloured urine (پیشاب کا رنگ گہرا ہونا) — highest risk in this Rolip Eze range due to 20mg statin component — stop immediately and seek emergency medical attention
- Liver damage (جگر کو نقصان) — yellowing of skin or eyes (یرقان), dark urine, severe fatigue — stop and consult doctor immediately
- Immune-mediated necrotising myopathy — IMNM — rare autoimmune muscle condition requiring specialist assessment
- Pancreatitis (لبلبے کی سوزش) — severe upper abdominal pain radiating to the back — rare but reported with Ezetimibe — seek immediate medical attention
- Severe allergic reaction (شدید الرجی) — facial swelling, difficulty breathing — seek emergency help immediately
Stop the medicine and contact your doctor immediately if any serious side effect occurs (فوری طور پر ڈاکٹر سے رابطہ کریں).
Drug Interactions
Always inform your doctor and pharmacist about all medicines you are currently taking (تمام ادویات کے بارے میں ڈاکٹر کو بتائیں).
| Medicine / Substance | Effect of Interaction |
|---|---|
| Cyclosporine (سائکلوسپورین) | Dramatically increases levels of both Rosuvastatin and Ezetimibe — contraindicated |
| Warfarin and anticoagulants (خون پتلا کرنے والی ادویات) | Rosuvastatin increases anticoagulant effect — monitor INR closely — important at 20mg |
| Fibrates — e.g. Gemfibrozil (کولیسٹرول کی ادویات) | Significantly increases myopathy risk and raises Ezetimibe levels — avoid Gemfibrozil — Fenofibrate with caution |
| Bile acid sequestrants — e.g. Cholestyramine | Reduces Ezetimibe absorption — take Rolip Eze at least 2 hours before or 4 hours after cholestyramine |
| Antacids containing aluminium and magnesium | Reduce Ezetimibe absorption — take Rolip Eze at least 2 hours before antacids |
| HIV protease inhibitors — e.g. Lopinavir, Ritonavir | Increase Rosuvastatin levels significantly — Rosuvastatin dose should not exceed 10mg with these agents — use of this 20mg combination not recommended |
| Oral contraceptives (مانع حمل گولیاں) | Rosuvastatin increases blood levels of some hormonal contraceptives — inform your doctor |
| Alcohol (شراب) | Increases liver damage risk — avoid excessive alcohol, particularly important at 20mg statin dose |
Storage Instructions
- Store below 25°C in a cool, dry place (ٹھنڈی اور خشک جگہ پر رکھیں)
- Keep away from direct sunlight and moisture (دھوپ اور نمی سے دور رکھیں)
- Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں)
- Do not use after the expiry date printed on the pack (میعاد ختم ہونے کے بعد استعمال نہ کریں)
- Store in the original packaging to protect from light
Frequently Asked Questions
What is Rolip Eze 10mg+20mg used for?
Rolip Eze 10mg+20mg combines Ezetimibe 10mg and Rosuvastatin 20mg to provide high-intensity dual-action cholesterol lowering — blocking both cholesterol production in the liver (جگر میں کولیسٹرول بننا بند کرتا ہے) and cholesterol absorption in the small intestine (چھوٹی آنت میں جذب ہونا بند کرتا ہے). Together they achieve LDL reductions of approximately 65 to 72% — making this one of the most powerful oral cholesterol-lowering options available. It is prescribed for patients with established heart disease, familial hypercholesterolaemia, or high cholesterol not adequately controlled on standard therapy.
What is the difference between Rolip Eze 10mg+10mg and 10mg+20mg?
Both products combine Ezetimibe 10mg with Rosuvastatin — but at different Rosuvastatin strengths. The 10mg+10mg contains standard-intensity Rosuvastatin 10mg — achieving approximately 60 to 70% combined LDL reduction — and is the appropriate starting combination for most patients. The 10mg+20mg contains high-intensity Rosuvastatin 20mg — achieving approximately 65 to 72% LDL reduction — reserved for patients with the highest cardiovascular risk, very high cholesterol, or inadequate LDL control on the lower combination. The 10mg+20mg carries a modestly higher risk of muscle side effects due to the higher statin dose.
Is Rolip Eze 10mg+20mg suitable for patients with heart disease?
Yes — this is one of the primary indications. Patients with established cardiovascular disease — including previous heart attack (دل کا دورہ), coronary artery disease, or stroke — are recommended to achieve LDL levels below 1.4 mmol/L (55 mg/dL) by current international cardiovascular guidelines. The 65 to 72% LDL reduction provided by Rolip Eze 10mg+20mg gives many of these patients the best chance of reaching this demanding target with a single daily oral tablet — reducing the risk of further cardiovascular events.
What are the most important muscle warning signs with Rolip Eze 10mg+20mg?
The Rosuvastatin 20mg component carries a greater muscle side effect risk than lower statin doses. Report promptly to your doctor if you develop unexplained muscle pain (پٹھوں میں درد), muscle weakness, or muscle tenderness — particularly if widespread or accompanied by dark or cola-coloured urine (پیشاب کا رنگ گہرا ہونا). Stop Rolip Eze immediately if these symptoms occur and seek urgent medical attention — dark urine alongside muscle pain may indicate rhabdomyolysis which can cause serious kidney damage if not treated promptly.
Can Rolip Eze 10mg+20mg be taken with HIV medicines?
No — this specific combination should not be used alongside HIV protease inhibitors such as Lopinavir or Ritonavir. These HIV medicines significantly increase Rosuvastatin blood levels — at the 20mg dose this increase could raise the risk of muscle damage to unacceptable levels. Patients on HIV protease inhibitors should not take Rosuvastatin above 10mg — meaning the Rolip Eze 10mg+10mg combination or separate lower-dose therapy would need to be considered instead. Always inform your doctor of all medicines including HIV treatments (تمام ادویات کے بارے میں ڈاکٹر کو بتائیں).
⚕️ Medical Disclaimer: This product description is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Rolip Eze 10mg+20mg is a high-intensity prescription combination medicine — always take it exactly as directed by your doctor. Stop immediately and seek urgent medical help if you develop severe muscle pain or dark urine. Women who are pregnant or planning pregnancy must not take this medicine. Regular cholesterol, liver, and kidney monitoring is essential during treatment.
DRAP Registered | Prescription Only (Rx) | For oral use only | Keep out of reach of children