Analgesic & Antipyretic | Form: Intramuscular (IM) Injection | Prescription Status: Prescription Only (Rx) — DRAP Registered
What is Provas Injection 300mg/2ml?
Provas Injection 300mg/2ml contains Paracetamol, one of the most widely used and trusted medicines in the world for relieving pain (درد) and reducing fever (بخار). It belongs to a group of medicines called analgesics and antipyretics — medicines that relieve pain and bring down high temperature. Unlike Paracetamol tablets or syrups taken by mouth, Provas Injection is given directly into the muscle, allowing the medicine to enter the bloodstream quickly and work faster. It is used when a patient cannot take medicines by mouth — such as after surgery, during severe vomiting, or when rapid fever control is urgently needed. Provas Injection must always be administered by a qualified doctor or trained nurse and must never be self-injected at home.
What is Provas Injection 300mg/2ml Used For?
Provas Injection 300mg/2ml is approved for the short-term treatment of the following conditions:
- Post-Operative Pain — moderate pain following a surgical procedure when the patient cannot take oral medicines (آپریشن کے بعد درد)
- Severe Fever (Pyrexia) — high body temperature caused by serious infection that requires rapid reduction (شدید بخار)
- Tonsillitis-Related Fever and Pain — fever and throat pain caused by tonsil infection (گلے کی سوزش سے بخار اور درد)
- Post-Immunisation Fever and Discomfort — fever and soreness following vaccination — particularly in children and infants (ویکسین کے بعد بخار)
- Moderate Acute Pain — pain that requires faster relief than oral medicine can provide
- Situations Where Oral Administration is Not Possible — vomiting, unconsciousness, difficulty swallowing, or restricted oral intake after surgery
How Does Provas Injection 300mg/2ml Work?
Paracetamol works through two important actions in the body:
Pain Relief (Analgesic Effect): Paracetamol raises the body's pain threshold by acting on pain-processing pathways in the brain and central nervous system. It reduces the perception of pain — meaning the brain receives a weaker pain signal, making moderate pain feel significantly less intense. Because Provas is given as an injection directly into the muscle, it bypasses the digestive system and reaches the bloodstream faster than an oral tablet — providing quicker pain relief when it is most needed.
Fever Reduction (Antipyretic Effect): When the body fights an infection, it produces chemicals called prostaglandins in the brain that raise body temperature — causing fever. Paracetamol blocks the production of these prostaglandins in the brain's temperature control centre, bringing the body temperature back down to a safe level. Again, the injection form achieves this more rapidly than oral Paracetamol — an important advantage when a patient has dangerously high fever that needs to be controlled quickly.
Dosage and Administration
⚠️ This injection must only be given by a qualified doctor or trained nurse. Do not attempt to self-inject at home. Do not exceed the maximum recommended daily dose of Paracetamol from all sources — check all other medicines being taken for Paracetamol content to avoid accidental overdose.
| Indication | Usual Adult Dose | Frequency |
|---|---|---|
| Moderate Post-Operative Pain | 300mg (2ml) IM | Every 4 to 6 hours as needed |
| Severe Fever (Adults) | 300mg (2ml) IM | Every 4 to 6 hours as needed |
| Tonsillitis Pain and Fever | 300mg (2ml) IM | Every 4 to 6 hours as needed |
| Post-Immunisation Reaction | Doctor-determined dose | Single or repeated dose as directed |
Important Dosing Rules:
- Maximum adult dose: Do not exceed 1g (1000mg) of Paracetamol per single dose or 4g (4000mg) in any 24-hour period from all sources combined
- In patients with liver disease, kidney disease, or chronic alcohol use — maximum daily dose must be reduced — doctor will specify
- Given as a deep intramuscular injection into a large muscle — usually the upper outer buttock or thigh
- Treatment should be switched to oral Paracetamol as soon as the patient is able to take medicines by mouth
- Duration of injectable treatment should be as short as possible — typically until oral medicines can be safely resumed
Paediatric Use:
- Dose in children is calculated based on body weight — typically 15mg per kg of body weight per dose
- Must only be given to children under direct medical supervision
- Your doctor will calculate the exact dose and frequency appropriate for the child's age and weight
Active Ingredient
| Ingredient | Strength per Ampoule |
|---|---|
| Paracetamol | 300mg per 2ml |
Who Should NOT Use Provas Injection 300mg/2ml?
Do not use this injection if the patient:
- Is allergic to Paracetamol or any other ingredient in the formulation
- Has severe liver disease or active liver failure (جگر کی شدید بیماری یا ناکامی)
- Has severe kidney disease (گردے کی شدید بیماری)
- Has a known condition called Gilbert's Syndrome combined with liver impairment
- Has been told by the doctor to avoid Paracetamol for any reason
Tell the doctor before use if the patient has:
- Any liver disease — including hepatitis, cirrhosis, or fatty liver — even mild
- Any kidney disease — dose reduction may be needed
- A history of regular heavy alcohol use (باقاعدہ شراب نوشی کی تاریخ) — increases risk of Paracetamol-related liver damage
- Low body weight or malnutrition — increased sensitivity to Paracetamol toxicity
- Glucose-6-phosphate dehydrogenase (G6PD) deficiency — a blood condition
- Is currently taking any other medicines containing Paracetamol — risk of overdose
- If the patient is pregnant or breastfeeding — doctor will assess safety before prescribing
Side Effects
Like all medicines, Provas Injection 300mg/2ml can cause side effects. Not everyone will experience them. Paracetamol is generally very well tolerated when used at the correct dose.
Common Side Effects (relatively frequent):
- Pain, redness, or mild swelling at the injection site
- Nausea (متلی) — mild and usually temporary
- Headache (سردرد)
- Dizziness — mild and short-lived in most cases
Serious Side Effects (less common — seek medical help immediately):
- Severe allergic reaction — sudden rash, widespread hives, swelling of the face, lips, or throat, difficulty breathing or drop in blood pressure (anaphylaxis)
- Liver damage — this is the most serious risk of Paracetamol and occurs with overdose or in patients with pre-existing liver disease. Signs include yellowing of skin or eyes (یرقان), dark urine, severe right-sided stomach pain, extreme tiredness
- Severe skin reactions — rare but serious blistering or peeling of the skin (Stevens-Johnson Syndrome) — seek emergency help immediately if skin begins to blister or peel after receiving this injection
- Significant drop in blood cell counts — unusual bruising, bleeding, or signs of infection (very rare)
- Low blood pressure immediately after injection in some patients — doctor will monitor
If any serious side effect occurs during or after the injection, inform the treating doctor or nurse immediately or go to the nearest hospital emergency.
Drug Interactions
Tell the doctor about ALL medicines the patient is currently taking. Provas Injection 300mg/2ml may interact with:
| Medicine / Substance | Possible Effect |
|---|---|
| Other Paracetamol-containing medicines (cold, flu, or combination pain remedies) | Risk of serious Paracetamol overdose and liver damage — never use together |
| Warfarin (blood thinner) | Regular or prolonged Paracetamol use may increase bleeding risk — monitor INR closely |
| Medicines for epilepsy (e.g., Phenytoin, Carbamazepine, Phenobarbitone) | May increase the risk of Paracetamol-related liver toxicity |
| Rifampicin (antibiotic) | May reduce the pain-relieving effect of Paracetamol |
| Isoniazid (tuberculosis medicine) | Increases risk of Paracetamol liver toxicity — use with caution |
| Metoclopramide or Domperidone (anti-nausea medicines) | May speed up Paracetamol absorption — generally used safely together but doctor should be aware |
| Cholestyramine (cholesterol medicine) | May reduce Paracetamol absorption if taken together — separate doses by at least one hour |
| Alcohol (شراب) | Significantly increases the risk of serious liver damage from Paracetamol — must be avoided |
Always inform the doctor about all medicines, vitamins, herbal products, or supplements the patient is taking before administering this injection.
Storage Instructions
- Store below 25°C in a cool, dry place
- Protect from light — keep ampoules in the outer carton until ready for use
- Keep away from direct sunlight and excessive heat
- Do not freeze the injection (منجمد نہ کریں)
- Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں)
- Do not use after the expiry date printed on the ampoule or outer carton
- Discard any unused portion of the ampoule immediately after use — never store an opened ampoule
- Do not use if the solution appears cloudy, discoloured, or contains visible particles
Frequently Asked Questions
What is Provas Injection 300mg/2ml used for?
Provas Injection is used for rapid relief of moderate pain and high fever when a patient cannot take medicines by mouth. Common situations include pain and fever after surgery, severe infection-related fever such as tonsillitis, and fever following vaccination. It is used in hospital and clinical settings for fast and reliable pain and fever control.
Why is the injection used instead of Paracetamol tablets or syrup?
The injection is chosen when oral medicines cannot be given — for example after surgery when the patient is not allowed to eat or drink, when the patient is vomiting and cannot keep tablets down, or when very fast fever or pain control is urgently needed. The injection delivers Paracetamol directly into the bloodstream much faster than a tablet absorbed through the stomach, making it more suitable for urgent situations.
Is Provas Injection the same as regular Paracetamol?
Yes — the active medicine is the same Paracetamol found in common tablets and syrups. The difference is the form and speed of delivery. The injection bypasses the digestive system and works faster, making it suitable for situations where quick action is needed or oral intake is not possible. Once the patient can take medicines by mouth, the doctor will switch to oral Paracetamol.
Can Provas Injection cause liver damage?
When used correctly at the recommended dose, Paracetamol is very safe and well tolerated. Liver damage only occurs with overdose or when Paracetamol is taken by patients who already have liver disease or who regularly consume large amounts of alcohol. This is why it is extremely important never to take additional Paracetamol-containing medicines at the same time as receiving Provas Injection. Always inform the treating doctor about all other medicines being taken.
Is Provas Injection safe for children?
Yes, Paracetamol injection can be used safely in children when the dose is correctly calculated based on the child's body weight. It must only be administered by a qualified doctor or nurse. Parents should never attempt to give this injection at home. The doctor will determine the appropriate dose and frequency for the child's age and weight.
Can Provas Injection be used during pregnancy?
Paracetamol is generally considered one of the safer pain relievers during pregnancy when used at the lowest effective dose for the shortest time possible. However, the injection form should only be used during pregnancy if clearly necessary and under direct medical supervision. Always inform the treating doctor if the patient is pregnant or breastfeeding before this injection is administered.
⚕️ Medical Disclaimer: This product description is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified doctor or pharmacist before starting, stopping, or changing any medication. This product is a prescription medicine — it must only be used under the supervision of a licensed healthcare professional.
DRAP Registered | Prescription Required (Rx) | For use under medical supervision only