Drug Class: Fluoroquinolone Antibiotic | Form: Tablets (Oral) | Prescription Status: Prescription Only (Rx) — DRAP Registered
What is Oflobid Tablets 400mg?
Oflobid Tablets 400mg contain Ofloxacin — a broad-spectrum fluoroquinolone antibiotic (وسیع اثر والی اینٹی بائیوٹک) used to treat a wide range of serious bacterial infections (جراثیمی انفیکشن). The 400mg tablet is the higher-strength formulation — used for more serious infections or conditions requiring a larger dose, such as pneumonia, typhoid fever, prostatitis, and pelvic inflammatory disease. Ofloxacin works by blocking the enzymes bacteria need to replicate their DNA — causing rapid bacterial cell death (جراثیم کا خاتمہ) rather than simply slowing bacterial growth. It is effective against a broad range of gram-positive and gram-negative bacteria. Oflobid 400mg is a prescription-only medicine — it must be taken exactly as directed by a doctor and is not effective against viral infections (وائرل انفیکشن جیسے نزلہ اور فلو پر اثر نہیں کرتی).
What is Oflobid 400mg Used For?
Oflobid Tablets 400mg is indicated for the treatment of bacterial infections in the following areas:
Respiratory Tract Infections (سانس کی نالی کا انفیکشن) — including community-acquired pneumonia (نمونیا), acute exacerbations of chronic bronchitis, and lower respiratory tract infections caused by susceptible organisms
Urinary Tract Infections — UTI (پیشاب کی نالی کا انفیکشن) — including complicated urinary tract infections, cystitis (مثانے کا انفیکشن), and pyelonephritis (گردے کا انفیکشن)
Typhoid Fever (ٹائیفائیڈ بخار) — treatment of Salmonella typhi infections — Ofloxacin is an effective option for typhoid in areas where the organism remains susceptible
Prostatitis (پروسٹیٹ کی سوزش) — bacterial infection of the prostate gland — Ofloxacin has excellent tissue penetration into the prostate making it highly effective for this condition
Pelvic Inflammatory Disease — PID (شرونی کی سوزش) — infection of the female reproductive organs — usually used in combination with other antibiotics for complete coverage
Sexually Transmitted Infections — STIs (جنسی طور پر منتقل ہونے والے انفیکشن) — including uncomplicated gonorrhoea (سوزاک) and chlamydia caused by susceptible organisms
Skin and Soft Tissue Infections (جلد اور نرم بافتوں کا انفیکشن) — including cellulitis (جلد کی گہرائی میں انفیکشن), infected wounds, and skin structure infections
Infectious Diarrhoea (انفیکشن سے اسہال) — treatment of bacterial gastroenteritis caused by susceptible organisms including Salmonella, Shigella, and Campylobacter
Abdominal Infections (پیٹ کے اندرونی انفیکشن) — used as part of combination therapy for intra-abdominal infections caused by susceptible bacteria
Tuberculosis — TB (تپ دق) — used as a second-line agent in combination regimens for drug-resistant or complicated tuberculosis — always under specialist supervision
How Does Oflobid 400mg Work?
Oflobid contains Ofloxacin — a second-generation fluoroquinolone antibiotic that works through a targeted mechanism against bacterial cells.
Bacteria depend on two enzymes — DNA gyrase and topoisomerase IV — to replicate and repair their DNA during cell division. Ofloxacin binds directly to both enzymes and blocks their activity — creating irreparable breaks in the bacterial DNA strand. Unable to copy their genetic material or divide, the bacteria die rapidly — making Ofloxacin a bactericidal antibiotic (جراثیم کو مار ڈالنے والی اینٹی بائیوٹک).
This mechanism is unique to bacterial cells — human cells do not use DNA gyrase or topoisomerase IV — making Ofloxacin selectively toxic to bacteria without directly damaging human cells at therapeutic doses.
The 400mg strength achieves higher blood and tissue concentrations than the 200mg — providing more robust bacterial killing for serious infections such as pneumonia, typhoid, and prostatitis where deeper tissue penetration and higher drug levels are needed for effective treatment.
Dosage and Administration
Oflobid Tablets must be taken exactly as prescribed by your doctor. Always complete the full prescribed course (پورا کورس مکمل کریں — درمیان میں بند نہ کریں).
| Infection Type | Typical Dose | Duration |
|---|---|---|
| Pneumonia / Respiratory Infection (نمونیا) | 400mg once or twice daily | 7 to 14 days |
| Complicated UTI (پیچیدہ UTI) | 400mg once or twice daily | 7 to 14 days |
| Typhoid Fever (ٹائیفائیڈ) | 400mg twice daily | 7 to 14 days |
| Prostatitis (پروسٹیٹ) | 400mg twice daily | 28 days |
| Pelvic Inflammatory Disease — PID | 400mg twice daily | 14 days — with other antibiotics |
| Uncomplicated Gonorrhoea (سوزاک) | 400mg as a single dose | Single dose |
| Skin and Soft Tissue Infection | 400mg once or twice daily | 7 to 14 days |
| Infectious Diarrhoea (اسہال) | 400mg once or twice daily | 3 to 7 days |
| TB (second-line — تپ دق) | As directed by TB specialist | As part of full TB regimen |
Important Administration Instructions:
- Swallow tablets whole with a full glass of water (پانی کے ساتھ پوری گولی نگلیں)
- Take on an empty stomach or with a light meal — avoid dairy products, antacids containing calcium, magnesium, or aluminium within 2 hours of Ofloxacin (یہ دوا کا اثر کم کر دیتے ہیں)
- Drink plenty of water throughout the day during treatment (دن بھر پانی زیادہ پئیں)
- Take doses at evenly spaced intervals — preferably at the same times each day
- Never stop early — even if symptoms improve — incomplete courses cause antibiotic resistance (ادھورا کورس جراثیم کو مزید مضبوط بنا دیتا ہے)
- If you miss a dose (خوراک بھول جائیں) — take it as soon as you remember. If it is almost time for the next dose, skip the missed one. Never double dose.
Active Ingredients
| Ingredient | Role |
|---|---|
| Ofloxacin 400mg | Fluoroquinolone antibiotic — inhibits bacterial DNA gyrase and topoisomerase IV to prevent DNA replication and cause bacterial cell death |
Also contains standard tablet excipients. Please check the product label or ask your pharmacist for full composition details.
Who Should NOT Use Oflobid 400mg?
Do not use Oflobid if you (استعمال نہ کریں اگر):
- Are allergic to Ofloxacin, any other fluoroquinolone antibiotic, or any other ingredient in the tablet (الرجی ہو)
- Have a history of tendon problems (پٹھوں کی نالی کی تکلیف) caused by fluoroquinolone antibiotics
- Have a history of seizures or epilepsy (مرگی یا دورے)
- Are under 18 years of age — not recommended due to risk of joint and cartilage damage (بچوں کے لیے نہیں)
- Are pregnant (حاملہ) or breastfeeding (دودھ پلانے والی ماں)
Tell your doctor before use if (ڈاکٹر کو بتائیں اگر):
- You have kidney or liver problems (گردے یا جگر کی بیماری) — dose reduction may be required
- You have heart disease or irregular heartbeat (دل کی دھڑکن کی خرابی) — fluoroquinolones can prolong the QT interval
- You have diabetes (ذیابیطس) — Ofloxacin can disturb blood sugar levels
- You are elderly (بزرگ) — higher risk of tendon rupture and heart rhythm effects
- You are taking blood thinners, antidiabetic medicines, or NSAIDs
Side Effects
Not everyone will experience side effects. Oflobid is generally well tolerated when used at the correct dose.
Common Side Effects (عام ضمنی اثرات):
- Nausea (متلی) and vomiting (قے) — usually mild
- Diarrhoea (اسہال) or abdominal discomfort (پیٹ کی تکلیف)
- Headache (سردرد) and dizziness (چکر آنا)
- Insomnia or sleep disturbance (نیند کی خرابی)
- Photosensitivity (دھوپ سے جلد کی حساسیت) — avoid prolonged sun exposure during treatment
Serious Side Effects (سنگین ضمنی اثرات — stop the medicine and seek medical help):
- Tendon pain or rupture (پٹھوں کی نالی میں درد یا ٹوٹنا) — stop immediately if tendon pain develops — risk is higher in elderly patients and those on corticosteroids
- Peripheral neuropathy (اعصاب کو نقصان) — tingling, numbness, or weakness in arms or legs — stop immediately
- CNS effects (دماغی اثرات) — confusion, hallucinations, tremors, or seizures — stop immediately
- QT prolongation and arrhythmia (دل کی دھڑکن کی خرابی) — palpitations, dizziness, or fainting — seek urgent attention
- Severe diarrhoea with blood or mucus (خونی اسہال) — may indicate C. difficile colitis — stop and seek medical assessment
- Severe allergic reaction (شدید الرجی) — blistering rash, swelling of face or throat, difficulty breathing — seek emergency help immediately
- Liver toxicity (جگر کو نقصان) — yellowing of skin or eyes (یرقان) — stop and consult doctor immediately
Stop the medicine and contact your doctor immediately if any serious side effect occurs (فوری طور پر ڈاکٹر سے رابطہ کریں).
Drug Interactions
Always inform your doctor and pharmacist about all medicines you are currently taking (تمام ادویات کے بارے میں ڈاکٹر کو بتائیں).
| Medicine / Substance | Effect of Interaction |
|---|---|
| Antacids — aluminium, magnesium, calcium (تیزابیت کی دوائیں) | Significantly reduce Ofloxacin absorption — take at least 2 hours apart |
| Iron and zinc supplements (آئرن اور زنک) | Reduce absorption — take with a 2-hour gap |
| Warfarin and anticoagulants (خون پتلا کرنے والی ادویات) | Increases anticoagulant effect — higher bleeding risk — monitor INR |
| NSAIDs — e.g. Ibuprofen, Diclofenac (درد کی ادویات) | Increased risk of seizures with fluoroquinolones |
| Antidiabetic medicines — Insulin, oral hypoglycaemics (ذیابیطس کی ادویات) | Blood sugar disturbances — monitor carefully |
| QT-prolonging medicines — e.g. Amiodarone, antipsychotics | Additive QT prolongation — risk of serious arrhythmia — avoid combination |
| Corticosteroids (سٹیرائڈز) | Significantly increases risk of tendon rupture — especially in elderly |
| Theophylline (دمہ کی دوا) | Ofloxacin increases Theophylline levels — risk of toxicity — monitor carefully |
Storage Instructions
- Store below 25°C in a cool, dry place (ٹھنڈی اور خشک جگہ پر رکھیں)
- Keep away from direct sunlight and moisture (دھوپ اور نمی سے دور رکھیں)
- Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں)
- Do not use after the expiry date printed on the pack (میعاد ختم ہونے کے بعد استعمال نہ کریں)
- Store in the original packaging to protect from light
Frequently Asked Questions (FAQs)
Q: What is Oflobid 400mg used for? Oflobid 400mg contains Ofloxacin — a broad-spectrum fluoroquinolone antibiotic used to treat serious bacterial infections (جراثیمی انفیکشن) including pneumonia, typhoid fever, prostatitis, pelvic inflammatory disease, urinary tract infections, STIs, skin infections, and infectious diarrhoea. It kills bacteria by blocking their DNA replication and is not effective against viral infections such as colds or flu (وائرل انفیکشن پر اثر نہیں).
Q: What is the difference between Oflobid 200mg and 400mg? Both tablets contain the same active ingredient — Ofloxacin — but at different strengths. The 200mg is used for milder or uncomplicated infections such as simple UTIs. The 400mg is prescribed for more serious infections — such as pneumonia, typhoid, prostatitis, and PID — where higher drug concentrations in the blood and tissues are needed for effective bacterial killing. Your doctor will prescribe the strength appropriate for your specific infection.
Q: Can Oflobid 400mg treat typhoid fever? Yes — Ofloxacin is an effective treatment for typhoid fever (ٹائیفائیڈ بخار) caused by Salmonella typhi in areas where the organism remains susceptible to fluoroquinolones. However, antibiotic resistance patterns for typhoid vary by region. Your doctor will assess local resistance patterns and confirm whether Ofloxacin is the appropriate choice for your specific case — particularly given rising fluoroquinolone-resistant typhoid in parts of Pakistan.
Q: Why should I avoid antacids while taking Oflobid? Antacids containing aluminium, magnesium, or calcium bind to Ofloxacin in the stomach and significantly reduce how much is absorbed into the bloodstream — reducing its effectiveness against infection. Take Oflobid at least 2 hours before or 2 hours after any antacid (تیزابیت کی دوا سے 2 گھنٹے پہلے یا بعد میں لیں). The same applies to iron and zinc supplements.
Q: What should I do if I develop tendon pain while on Oflobid? Stop Oflobid immediately and contact your doctor (فوری طور پر ڈاکٹر سے رابطہ کریں). Fluoroquinolone antibiotics can rarely cause tendon inflammation and rupture — most commonly the Achilles tendon. Rest the affected limb completely and avoid exercise until assessed by a doctor. Risk is significantly higher in elderly patients and those taking corticosteroid medicines.
⚕️ Medical Disclaimer: This product description is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Oflobid is a prescription antibiotic — always take it exactly as directed by your doctor and complete the full course. Do not use this medicine to self-treat infections. Antibiotic resistance is a serious public health concern — use antibiotics only when prescribed by a qualified doctor.
DRAP Registered | Prescription Only (Rx) | For oral use only | Keep out of reach of children