Drug Class: NSAID — Preferential COX-2 Inhibitor | Form: Oral Tablet | Prescription Status: Prescription Only (Rx) — DRAP Registered
What is Nise 100mg Tablet? Nise 100mg contains Nimesulide — a preferential COX-2 inhibiting NSAID used for short-term management of acute pain, inflammation, and fever. Unlike traditional NSAIDs that equally block both COX-1 and COX-2 enzymes, Nimesulide preferentially targets COX-2 — the enzyme more directly responsible for inflammation — while relatively sparing COX-1, which protects the stomach lining. However, due to concerns about liver toxicity with prolonged use, Nimesulide is strictly recommended for short-term use only — generally not exceeding 15 days — and must always be taken under medical supervision with food.
What is Nise 100mg Used For?
- Acute osteoarthritis pain — joint pain and stiffness flare-ups (جوڑوں کا شدید درد)
- Dysmenorrhoea — menstrual cramps and period pain (ماہواری کا درد)
- Dental pain and post-dental procedure pain (دانت کا درد)
- Post-operative pain with inflammatory component (آپریشن کے بعد درد)
- Acute musculoskeletal pain — sprains and soft tissue injuries (پٹھوں کی چوٹ)
- Fever with pain — short-term symptomatic relief (بخار اور درد)
How Does it Work? Nimesulide preferentially inhibits COX-2 enzyme — blocking prostaglandin production at sites of inflammation and in the hypothalamus where fever is regulated. By targeting COX-2 more selectively, it reduces pain and inflammation with comparatively less inhibition of COX-1 — the enzyme responsible for producing stomach-protecting prostaglandins. It also has additional anti-inflammatory properties beyond COX inhibition including inhibition of certain inflammatory mediators, contributing to its overall effectiveness.
Dosage and Administration
⚠️ Strictly short-term use only — do not exceed 15 consecutive days. Always take with food. Never combine with other NSAIDs, Aspirin above 75mg, or Paracetamol-containing products during Nimesulide therapy. Avoid alcohol completely during treatment.
| Indication | Usual Adult Dose | Frequency | Maximum Duration |
|---|---|---|---|
| Acute pain / Osteoarthritis | 100mg | Twice daily | 15 days maximum |
| Dysmenorrhoea | 100mg | Twice daily | Short-term only |
| Dental / Post-operative pain | 100mg | Twice daily | 15 days maximum |
| Fever with pain | 100mg | Twice daily | 15 days maximum |
Active Ingredients
| Ingredient | Strength |
|---|---|
| Nimesulide | 100mg |
Who Should NOT Take Nise 100mg?
- Allergy to Nimesulide, Aspirin, or any other NSAID
- Active stomach ulcer or history of gastrointestinal bleeding
- Any liver disease or abnormal liver function — Nimesulide is contraindicated in all liver conditions
- Severe kidney impairment
- Severe heart failure or established cardiovascular disease
- Third trimester of pregnancy
- Children and adolescents under 18 years — strictly contraindicated
- Aspirin-sensitive asthma
- Alcohol dependence or regular heavy alcohol use
- Patients taking other hepatotoxic medicines
Side Effects
Common: Nausea, stomach discomfort, heartburn, mild dizziness, skin rash — reduced by always taking with food.
Serious — Stop and seek emergency help immediately: Yellowing of skin or eyes (یرقان — فوری ہسپتال جائیں), dark urine or pale stools indicating liver damage, severe upper abdominal pain, dark tarry stools or vomiting blood (پیٹ سے خون — فوری مدد لیں), severe allergic reaction with swelling of face or throat and difficulty breathing, significant reduction in urination indicating kidney problems, severe skin blistering or peeling.
Drug Interactions
| Medicine | Interaction |
|---|---|
| Other NSAIDs or Aspirin above 75mg | Greatly increased gastrointestinal bleeding and liver toxicity risk — never combine |
| Paracetamol | Combined use increases liver toxicity risk — avoid simultaneous use |
| Warfarin / blood thinners | Increased bleeding risk — close INR monitoring required |
| Antihypertensives (ACE inhibitors, ARBs, diuretics) | Nimesulide reduces their effectiveness and raises blood pressure |
| Methotrexate | Nimesulide increases Methotrexate toxicity — avoid combination |
| Cyclosporine | Increased kidney toxicity risk — avoid combination |
| Lithium | Nimesulide increases Lithium blood levels — monitor closely |
| Alcohol (شراب) | Severely increases liver damage risk — avoid completely during treatment |
Storage: Store below 25°C in a cool, dry place. Protect from moisture and direct sunlight. Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں). Do not use after expiry date.
FAQs
Q: Why is Nise 100mg limited to 15 days maximum use? Nimesulide carries a risk of serious liver toxicity with prolonged use — this risk increases significantly beyond 15 days. Always complete the shortest course needed and never extend without direct doctor advice.
Q: Can children take Nise 100mg for fever or pain? No — Nimesulide is strictly contraindicated in children and adolescents under 18 years due to serious liver toxicity risk. Paracetamol remains the recommended medicine for fever and pain in children.
Q: Is Nise 100mg safer on the stomach than regular NSAIDs? Nimesulide preferentially spares the stomach-protecting COX-1 enzyme more than traditional NSAIDs — however stomach irritation is still possible and taking with food is always required to minimise this risk.
⚕️ Medical Disclaimer: This information is for general awareness only and does not replace medical advice. Always consult a qualified doctor or pharmacist before taking any prescription medicine.