Drug Class: Dual Antiplatelet Combination | Form: Oral Tablet | Prescription Status: Prescription Only (Rx) — DRAP Registered
What is Lowplat Plus Tablet? Lowplat Plus is a fixed-dose combination of Clopidogrel 75mg and Aspirin 75mg — two antiplatelet medicines that work through different mechanisms to prevent dangerous blood clots forming inside blood vessels. It is prescribed for patients who have had a heart attack, stroke, or who have undergone coronary stent placement — where keeping blood flowing freely through vessels is critical. Both medicines together provide stronger clot prevention than either medicine alone.
What is Lowplat Plus Used For?
- Prevention of heart attack (دل کا دورہ) in high-risk patients
- Prevention of stroke (فالج) in patients with blocked arteries
- Keeping coronary stents open after angioplasty procedure
- Peripheral artery disease — reduced blood flow to legs (ٹانگوں میں خون کی کمی)
- Acute coronary syndrome — unstable angina and related conditions
How Does it Work? Clopidogrel blocks ADP receptors on platelets, preventing them from clumping together. Aspirin irreversibly inhibits COX-1 enzyme, reducing thromboxane A2 — another substance that triggers platelet clotting. Together they block two separate clotting pathways simultaneously, significantly reducing the risk of dangerous clot formation in arteries.
Dosage and Administration
⚠️ Never stop this medicine without consulting your doctor — stopping suddenly increases risk of heart attack or stent blockage. Always take with food.
| Indication | Usual Adult Dose | Frequency |
|---|---|---|
| Post-stent / ACS | 1 tablet | Once daily |
| Stroke / Heart attack prevention | 1 tablet | Once daily |
Active Ingredients
| Ingredient | Strength |
|---|---|
| Clopidogrel | 75mg |
| Aspirin | 75mg |
Who Should NOT Take Lowplat Plus?
- Active bleeding — stomach ulcer or bleeding inside the brain
- Allergy to Clopidogrel, Aspirin, or any NSAID
- Severe liver disease
- Children and teenagers under 18
- Third trimester of pregnancy
- Currently taking full-dose Aspirin above 100mg from another source
Side Effects
Common: Easy bruising, prolonged bleeding from cuts, stomach discomfort, nausea.
Serious — Stop and seek emergency help immediately: Vomiting blood or dark tarry stools (پیٹ سے خون — فوری ڈاکٹر کو دکھائیں), blood in urine, sudden severe headache, vision changes, signs of stroke — weakness on one side of body (فالج کی علامات), unusual prolonged bleeding from any site.
Drug Interactions
| Medicine | Interaction |
|---|---|
| Warfarin / other blood thinners | Seriously increased bleeding risk — avoid combination |
| NSAIDs (Ibuprofen, Diclofenac) | Increased gastrointestinal bleeding risk |
| Omeprazole / Esomeprazole | May reduce Clopidogrel effectiveness — consult doctor |
| SSRIs (Fluoxetine, Sertraline) | Increased bleeding risk with antiplatelet combination |
| Methotrexate | Aspirin increases Methotrexate toxicity |
Storage: Store below 25°C in a cool, dry place. Protect from moisture. Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں). Do not use after expiry date.
FAQs
Q: Can I stop Lowplat Plus if I feel fine? Never stop without your doctor's instruction — sudden stopping after a stent can cause life-threatening clot formation inside the stent within hours.
Q: Is it safe to take other pain medicines like Ibuprofen with Lowplat Plus? No — combining NSAIDs like Ibuprofen significantly increases stomach bleeding risk. Always ask your doctor before taking any additional pain medicine.
Q: Why does Lowplat Plus contain two medicines instead of one? Clopidogrel and Aspirin block two different clotting pathways — together they are significantly more effective at preventing dangerous blood clots than either medicine alone.