Drug Class: Non-Steroidal Anti-Inflammatory Drug (NSAID) | Form: Sustained-Release Tablet | Prescription Status: Prescription-Only (Rx) — DRAP Registered
What is Calgesic SR 750mg?
Calgesic SR 750mg is a prescription sustained-release NSAID tablet containing Naproxen 750mg, designed to release the active ingredient slowly and steadily over an extended period. The SR formulation provides longer-lasting pain and inflammation relief (درد اور سوجن) compared to standard-release Naproxen tablets, making it particularly suitable for chronic conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis that require consistent, round-the-clock control. The sustained-release design also reduces the frequency of dosing needed throughout the day, improving convenience for patients on long-term treatment.
What is Calgesic SR 750mg Used For?
Rheumatoid Arthritis: Provides sustained relief from joint pain, swelling, and morning stiffness associated with this chronic autoimmune condition. Osteoarthritis: Manages ongoing pain and swelling in weight-bearing joints such as the knees and hips caused by cartilage wear. Ankylosing Spondylitis: Controls spine inflammation, stiffness, and pain in this chronic inflammatory joint disease. Chronic Musculoskeletal Disorders: Reduces persistent inflammation and discomfort from long-term muscle and joint injuries or overuse conditions.
How Does Calgesic SR 750mg Work?
Naproxen inhibits cyclooxygenase (COX-1 and COX-2) enzymes, which the body uses to produce prostaglandins, the chemicals responsible for causing pain, inflammation, and fever. The sustained-release formulation allows Naproxen to be absorbed gradually from the tablet over several hours, maintaining a steady level of the medicine in the bloodstream. This provides more consistent and prolonged pain control compared to standard-release tablets, reducing the peaks and troughs in drug levels that can lead to breakthrough pain.
Dosage and Administration
| Situation | Dose | Frequency |
|---|---|---|
| Chronic arthritis and joint conditions | 1 tablet (750mg) | Once or twice daily as prescribed |
| As prescribed | Follow doctor's instructions | Do not crush or chew the tablet |
Take with food or milk to reduce stomach upset. Swallow the tablet whole with a full glass of water. Do not crush, break, or chew as this destroys the sustained-release mechanism and releases the full dose at once.
Active Ingredient
| Ingredient | Role |
|---|---|
| Naproxen 750mg (Sustained-Release) | NSAID — inhibits COX enzymes to reduce prostaglandin production, providing prolonged pain and inflammation relief |
Who Should NOT Use Calgesic SR 750mg?
Do not use if you have a known allergy to Naproxen, Aspirin, or any other NSAID. Tell your doctor if you have a history of stomach ulcers, kidney disease, liver disease, heart disease, or bleeding disorders. Avoid use in the third trimester of pregnancy. Inform your doctor if you are breastfeeding or taking blood-thinning medicines.
Side Effects
Common: Nausea, stomach upset, heartburn, headache, dizziness, constipation. Serious (seek immediate help): Signs of stomach bleeding including black or bloody stools or severe stomach pain. Signs of kidney or liver problems including swelling, dark urine, or yellowing of skin. Chest pain or shortness of breath. Severe allergic reaction including facial swelling or difficulty breathing.
Storage
Store below 30°C in a dry place away from direct sunlight. Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں). Do not use after the expiry date. Store in original packaging to protect from moisture.
Frequently Asked Questions
Can I crush or break Calgesic SR 750mg tablets?
No. Calgesic SR tablets must be swallowed whole. Crushing or breaking the tablet destroys the sustained-release coating and releases the entire 750mg dose at once, which increases the risk of side effects and removes the benefit of extended pain control.
How is Calgesic SR 750mg different from Calgesic 500mg?
Calgesic 500mg is a standard-release tablet that releases Naproxen quickly and requires dosing two or more times daily. Calgesic SR 750mg releases Naproxen slowly over a longer period, providing more consistent pain control with fewer doses. The SR formulation is generally preferred for chronic conditions requiring long-term daily management.
Medical Disclaimer: This description is for informational purposes only and does not replace professional medical advice. Always follow your doctor's prescription and consult your pharmacist for personal guidance.
DRAP Registered | Prescription Required (Rx) | Pain and Inflammation | Sustained-Release NSAID