Drug Class: Antifibrinolytic Agent — Haemostatic | Form: Injection / Intravenous Solution (5ml Ampoule) | Prescription Status: Prescription Only (Rx) — DRAP Registered
What is Transamin Injection 500mg?
Transamin Injection 500mg is a sterile injectable solution containing Tranexamic Acid 100mg/mL — supplied in a 5ml ampoule delivering a total dose of 500mg. It is an antifibrinolytic medicine (خون کے لوتھڑے کو محفوظ رکھنے والی دوا) used to control or prevent serious excessive bleeding (ضرورت سے زیادہ خون بہنا) in hospital and clinical settings. The 500mg ampoule is a higher-strength formulation compared to the 250mg — allowing a full therapeutic dose to be delivered from a single ampoule in many clinical situations, reducing the need for multiple ampoules and simplifying administration. Like all Tranexamic Acid preparations, it works by blocking the proteins responsible for breaking down blood clots — stabilising clots and reducing blood loss. Transamin Injection 500mg is a prescription-only medicine administered exclusively by or under the supervision of a qualified healthcare professional (صحت کے ماہر کی نگرانی میں).
What is Transamin Injection 500mg Used For?
Transamin Injection 500mg is indicated for the control and prevention of the following conditions:
Heavy Menstrual Bleeding — Menorrhagia (حیض میں بہت زیادہ خون آنا) — used when parenteral treatment is required for severe menstrual blood loss that cannot be managed with oral preparations alone
Surgical Bleeding (آپریشن کے دوران خون بہنا) — administered before, during, and after surgical operations to reduce blood loss and minimise the need for blood transfusions (خون چڑھانے کی ضرورت کم کرتا ہے) — including gynaecological, cardiac, orthopaedic, and dental surgery
Trauma-Related Bleeding (چوٹ سے خون بہنا) — used in emergency and critical care settings to control significant or life-threatening bleeding following serious injury — early administration significantly improves outcomes
Urinary Tract Bleeding (پیشاب کی نالی سے خون بہنا) — management of haematuria (خون والا پیشاب) caused by surgical procedures, trauma, or urological conditions — administered with caution due to the risk of clot obstruction
Haemoptysis in Tuberculosis (تپ دق میں کھانسی کے ساتھ خون آنا) — used to manage blood in sputum caused by pulmonary tuberculosis (پھیپھڑوں کی تپ دق)
Bleeding Associated with Blood Disorders (خون کی بیماریوں میں خون بہنا) — used in conditions such as aplastic anaemia (خون کی کمی کی بیماری), purpura, leukaemia, and cancer-related bleeding where clotting is impaired
Hereditary Angioedema (موروثی سوجن کی بیماری) — management and prevention of episodes causing sudden swelling of the skin, mucous membranes, and internal organs
How Does Transamin Injection 500mg Work?
Transamin Injection contains Tranexamic Acid — a synthetic amino acid (مصنوعی امینو ایسڈ) that acts as an antifibrinolytic agent by competitively blocking plasminogen (پلازمینوجن).
When a blood clot forms to stop bleeding, the body activates plasminogen — converting it into plasmin, an enzyme that dissolves the clot. In conditions involving excessive bleeding, this process occurs too rapidly — dissolving protective clots before adequate healing has taken place.
Tranexamic Acid binds to plasminogen molecules and blocks them from attaching to the fibrin clot structure — preventing premature clot breakdown (لوتھڑے کو قبل از وقت ٹوٹنے سے روکتا ہے). This stabilises the clot, reduces blood loss, and allows the body sufficient time to complete natural healing.
The 500mg ampoule delivers twice the dose of the 250mg ampoule in the same 5ml volume — at a concentration of 100mg/mL. This higher concentration is used when a larger dose is required in a single ampoule — particularly in surgical and trauma settings where speed and efficiency of preparation matter.
Dosage and Administration
Transamin Injection must be administered exactly as directed by a doctor or healthcare professional. It is not for self-administration (خود انجیکشن نہ لگائیں — یہ صرف ہسپتال یا کلینک میں دیا جاتا ہے).
| Indication | Typical Dose | Route & Notes |
|---|---|---|
| Surgical bleeding prevention | 0.5g to 1g slowly IV before surgery | Repeat every 6 to 8 hours as directed by surgeon |
| Trauma haemorrhage | 1g IV over 10 minutes — then 1g IV over 8 hours | Begin as early as possible after injury |
| Heavy menstrual / gynaecological bleeding | 0.5g to 1g two to three times daily | IV as directed by doctor |
| Haemoptysis in TB | 500mg two to three times daily | IV as directed |
| Urinary tract bleeding | As directed by urologist | IV — with caution due to clot obstruction risk |
| Dental surgery (bleeding disorders) | 10mg/kg body weight IV before procedure | Repeat every 8 hours as needed |
Important Administration Notes:
- Administered intravenously (IV) or intramuscularly (IM) by a trained healthcare professional only
- IV injection must be given slowly — at a rate not exceeding 1mL per minute — rapid injection can cause dizziness and a sudden drop in blood pressure (تیز انجیکشن سے چکر اور بلڈ پریشر کم ہو سکتا ہے)
- May be diluted in standard IV fluids including normal saline, dextrose solutions, and Ringer's solution
- Do not mix with blood products or penicillin in the same infusion line
- Renal impairment (گردے کی بیماری) requires dose reduction — your doctor will adjust accordingly
Active Ingredients
| Ingredient | Concentration | Role |
|---|---|---|
| Tranexamic Acid | 100mg/mL (500mg per 5ml ampoule) | Antifibrinolytic agent — blocks plasminogen to prevent premature clot breakdown and control excessive bleeding |
Also contains sterile water for injection and other standard excipients. Please check the product label for full composition details.
Who Should NOT Use Transamin Injection 500mg?
Do not use Transamin Injection if you (استعمال نہ کریں اگر):
- Are allergic to Tranexamic Acid or any other ingredient in the formulation (الرجی ہو)
- Have a history of blood clots (خون کے لوتھڑے) — including deep vein thrombosis, pulmonary embolism, or stroke (فالج)
- Have a history of convulsions or seizures (مرگی یا دورے)
- Have severe kidney disease (گردے کی شدید بیماری) without appropriate dose adjustment
- Are experiencing active upper urinary tract bleeding (پیشاب کی نالی میں خون آنا) — risk of clot obstruction in the ureter
Tell your doctor before use if (ڈاکٹر کو بتائیں اگر):
- You have kidney problems (گردے کی بیماری) — dose reduction is required
- You have a history of thrombosis (خون کا لوتھڑا بننا) or cardiovascular disease (دل کی بیماری)
- You are taking hormonal contraceptives (ہارمونل مانع حمل ادویات) — combined use increases clot risk
- You are pregnant (حاملہ) or breastfeeding (دودھ پلانے والی ماں) — use only if clearly necessary and under medical supervision
- You have any eye condition or colour vision impairment — long-term use has rarely been associated with visual disturbances
Side Effects
Not everyone will experience side effects. Transamin Injection is generally well tolerated when administered correctly at the appropriate rate.
Common Side Effects (عام ضمنی اثرات):
- Nausea (متلی) and vomiting (قے) — more likely with rapid IV injection
- Dizziness (چکر آنا) and low blood pressure — particularly if IV is administered too quickly
- Headache (سردرد)
- Abdominal discomfort (پیٹ کی تکلیف)
- Pain or discomfort at the injection site (انجیکشن کی جگہ پر تکلیف)
Serious Side Effects (سنگین ضمنی اثرات — seek immediate medical help):
- Blood clot formation (خون کا لوتھڑا بننا) — signs include sudden leg pain or swelling, chest pain, shortness of breath (سانس لینے میں تکلیف), or sudden severe headache — requires immediate medical attention
- Seizures or convulsions (دورے پڑنا) — reported at high IV doses — stop administration immediately and inform the treating doctor
- Visual disturbances (نظر میں خرابی) — blurred vision or colour vision changes — discontinue and refer to eye specialist
- Allergic reaction (الرجی) — rash, swelling of face or throat, difficulty breathing — seek emergency help immediately
Any serious adverse reaction must be reported to the administering healthcare professional immediately (فوری طور پر ڈاکٹر کو بتائیں).
Drug Interactions
Always inform your doctor about all medicines currently being administered (تمام ادویات کے بارے میں ڈاکٹر کو بتائیں).
| Medicine / Substance | Effect of Interaction |
|---|---|
| Combined hormonal contraceptives — OCP (مانع حمل گولیاں) | Significantly increases risk of blood clot formation — use with extreme caution |
| Factor IX complex / Anti-inhibitor coagulant concentrates | Increased risk of thrombosis (خون کا لوتھڑا) — avoid combination |
| Tretinoin (all-trans retinoic acid) | May increase risk of thrombotic complications |
| Anticoagulants — e.g. Warfarin (خون پتلا کرنے والی ادویات) | Tranexamic Acid opposes anticoagulant effects — requires careful monitoring |
| Penicillin and blood products | Do not mix in the same IV line — chemical incompatibility |
| Other haemostatic agents | Additive effect — increased clot risk — use only under medical supervision |
Storage Instructions
- Store below 25°C in a cool, dry place (ٹھنڈی اور خشک جگہ پر رکھیں)
- Keep away from direct sunlight and moisture (دھوپ اور نمی سے دور رکھیں)
- Do not freeze the ampoules (منجمد نہ کریں)
- Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں)
- Do not use after the expiry date printed on the ampoule or outer box (میعاد ختم ہونے کے بعد استعمال نہ کریں)
- Do not use if the solution appears discoloured or contains visible particles
- Discard any unused solution after single use — do not store opened ampoules
Frequently Asked Questions (FAQs)
Q: What is Transamin Injection 500mg used for? Transamin Injection 500mg contains Tranexamic Acid — an antifibrinolytic medicine used to control serious excessive bleeding (ضرورت سے زیادہ خون بہنا) in hospital settings. It is used during and after surgery, in trauma emergencies, for heavy menstrual bleeding requiring injectable treatment, urinary tract bleeding, haemoptysis in tuberculosis, and bleeding associated with blood disorders. It works by preventing blood clots from breaking down prematurely.
Q: What is the difference between Transamin Injection 250mg and 500mg? Both ampoules contain the same active ingredient — Tranexamic Acid — in the same 5ml volume, but at different concentrations. The 250mg ampoule contains 50mg/mL while the 500mg ampoule contains 100mg/mL. The 500mg ampoule is used when a higher dose is required from a single ampoule — improving clinical efficiency in surgical and emergency settings. Your doctor or clinical team will decide which strength is appropriate for your treatment.
Q: Can Transamin Injection 500mg be self-administered at home? No — Transamin Injection must only be administered by a trained healthcare professional (صرف تربیت یافتہ طبی عملہ انجیکشن لگا سکتا ہے) in a hospital, clinic, or appropriate medical setting. Incorrect administration can cause serious side effects including low blood pressure and seizures.
Q: Why must the IV injection be given slowly? Rapid intravenous injection of Tranexamic Acid can cause a sudden drop in blood pressure (بلڈ پریشر کا اچانک گرنا), dizziness, and nausea. The recommended rate is no faster than 1mL per minute. In most clinical settings it is administered as a slow infusion diluted in IV fluids to ensure patient safety and comfort.
Q: What warning signs of a blood clot should be reported after receiving this injection? Signs of a dangerous blood clot (خون کا لوتھڑا) include sudden pain, redness or swelling in the leg, chest pain, shortness of breath, or sudden severe headache. Any of these symptoms after receiving Transamin Injection must be reported to the treating doctor or nursing staff immediately (فوری طور پر طبی عملے کو بتائیں).
⚕️ Medical Disclaimer: This product description is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Transamin Injection is a prescription medicine for hospital and clinical use only — it must be administered exclusively by or under the direct supervision of a qualified healthcare professional. This product is not for self-administration.
DRAP Registered | Prescription Only (Rx) | For IV / IM use by healthcare professionals only | Keep out of reach of children