Drug Class: Antifibrinolytic Agent — Haemostatic | Form: Injection / Intravenous Solution (5ml Ampoule) | Prescription Status: Prescription Only (Rx) — DRAP Registered
What is Transamin Injection 250mg?
Transamin Injection 250mg is a sterile injectable solution containing Tranexamic Acid 50mg/mL — supplied in a 5ml ampoule delivering a total dose of 250mg. It is an antifibrinolytic medicine (خون کے لوتھڑے کو محفوظ رکھنے والی دوا) used to control or prevent serious and life-threatening excessive bleeding (ضرورت سے زیادہ خون بہنا) in hospital and clinical settings. The injectable form is used when rapid action is needed — such as during surgery, following trauma, or when a patient cannot take oral medicines. Like all Tranexamic Acid preparations, it works by blocking the proteins responsible for breaking down blood clots — allowing clots to remain stable and reducing blood loss. Transamin Injection is a prescription-only medicine administered exclusively by or under the supervision of a healthcare professional (صحت کے ماہر کی نگرانی میں).
What is Transamin Injection 250mg Used For?
Transamin Injection 250mg is indicated for the control and prevention of the following conditions:
Surgical Bleeding (آپریشن کے دوران خون بہنا) — administered before, during, and after surgical operations to reduce blood loss and minimise the need for blood transfusions (خون چڑھانے کی ضرورت کم کرتا ہے) — including general surgery, orthopaedic, cardiac, and obstetric procedures
Trauma-Related Bleeding (چوٹ سے خون بہنا) — used in emergency and critical care settings to control significant or life-threatening bleeding following serious injury — early administration significantly improves outcomes
Dental Surgery Bleeding (دانت کے آپریشن کے بعد خون بہنا) — controls bleeding following tooth extractions and oral surgical procedures — particularly in patients with bleeding disorders or those on anticoagulant therapy
Haemoptysis in Tuberculosis (تپ دق میں کھانسی کے ساتھ خون آنا) — used to manage blood in sputum caused by pulmonary tuberculosis (پھیپھڑوں کی تپ دق)
Abnormal Uterine Bleeding (بچہ دانی سے غیر معمولی خون بہنا) — management of excessive or abnormal bleeding from the uterus when parenteral treatment is required
Bleeding Associated with Blood Disorders (خون کی بیماریوں میں خون بہنا) — used in conditions such as aplastic anaemia (خون کی کمی کی بیماری), purpura, leukaemia, and cancer-related bleeding disorders where platelet function or clotting is impaired
Hereditary Angioedema (موروثی سوجن کی بیماری) — used to manage and prevent episodes of hereditary angioedema — a condition causing sudden swelling of the skin, mucous membranes, and internal organs
Prostate-Related Bleeding (پروسٹیٹ سے خون بہنا) — management of abnormal bleeding from the prostate — including post-operative haemorrhage following prostate surgery
How Does Transamin Injection Work?
Transamin Injection contains Tranexamic Acid — a synthetic amino acid (مصنوعی امینو ایسڈ) that acts as an antifibrinolytic agent by competitively blocking plasminogen (پلازمینوجن).
When a blood clot forms to stop bleeding, the body eventually activates plasminogen — converting it into plasmin, an enzyme that dissolves the clot. In conditions involving excessive or abnormal bleeding, this process occurs too rapidly — dissolving protective clots before adequate healing has taken place.
Tranexamic Acid binds to plasminogen molecules and blocks them from attaching to the fibrin clot structure — preventing premature clot breakdown (لوتھڑے کو قبل از وقت ٹوٹنے سے روکتا ہے). This stabilises the clot, reduces blood loss, and allows the body sufficient time to complete natural healing.
The injectable route delivers Tranexamic Acid directly into the bloodstream — achieving rapid, predictable therapeutic levels that are not dependent on absorption from the digestive system. This makes the injection the preferred route in emergency, surgical, and critical care situations where speed and reliability of action are essential.
Dosage and Administration
Transamin Injection must be administered exactly as directed by a doctor or healthcare professional. It is not for self-administration (خود انجیکشن نہ لگائیں — یہ صرف ہسپتال یا کلینک میں دیا جاتا ہے).
| Indication | Typical Dose | Route & Notes |
|---|---|---|
| Surgical bleeding prevention | 0.5g to 1g (10–20ml) slowly IV before surgery | Repeat every 6 to 8 hours as directed |
| Trauma haemorrhage | 1g IV over 10 minutes — then 1g IV over 8 hours | Begin as early as possible after injury |
| Local fibrinolysis / general haemorrhage | 0.5g to 1g two to three times daily | IV or IM as directed by doctor |
| Haemoptysis in TB | 250mg to 500mg two to three times daily | IV as directed |
| Dental surgery (patients with bleeding disorders) | 10mg/kg body weight IV before procedure | Repeat every 8 hours as needed |
Important Administration Notes:
- Administered intravenously (IV) or intramuscularly (IM) by a trained healthcare professional only
- IV injection must be given slowly — at a rate not exceeding 1mL (50mg) per minute — rapid injection can cause dizziness and low blood pressure (تیز انجیکشن سے چکر اور بلڈ پریشر کم ہو سکتا ہے)
- May be mixed with standard IV fluids including normal saline, dextrose solutions, and Ringer's solution
- Do not mix with blood products or penicillin in the same infusion line
- Renal impairment (گردے کی بیماری) requires dose reduction — your doctor will adjust accordingly
Active Ingredients
| Ingredient | Concentration | Role |
|---|---|---|
| Tranexamic Acid | 50mg/mL (250mg per 5ml ampoule) | Antifibrinolytic agent — blocks plasminogen to prevent premature clot breakdown and control excessive bleeding |
Also contains sterile water for injection and other standard excipients. Please check the product label for full composition details.
Who Should NOT Use Transamin Injection?
Do not use Transamin Injection if you (استعمال نہ کریں اگر):
- Are allergic to Tranexamic Acid or any other ingredient in the formulation (الرجی ہو)
- Have a history of blood clots (خون کے لوتھڑے) — including deep vein thrombosis, pulmonary embolism, or stroke (فالج)
- Have a history of convulsions or seizures (مرگی یا دورے)
- Have severe kidney disease (گردے کی شدید بیماری) without dose adjustment
- Are experiencing active bleeding in the upper urinary tract (پیشاب کی نالی میں خون آنا) — risk of clot obstruction in the ureter
Tell your doctor before use if (ڈاکٹر کو بتائیں اگر):
- You have kidney problems (گردے کی بیماری) — dose reduction is required
- You have a history of thrombosis (خون کا لوتھڑا بننا) or cardiovascular disease (دل کی بیماری)
- You are taking hormonal contraceptives (ہارمونل مانع حمل ادویات) — combined use increases clot risk
- You are pregnant (حاملہ) or breastfeeding (دودھ پلانے والی ماں) — use only if clearly needed and under medical supervision
- You have a colour vision impairment or any eye condition — long-term use has rarely been associated with visual disturbances
Side Effects
Not everyone will experience side effects. The injection form is generally well tolerated when administered correctly by a healthcare professional.
Common Side Effects (عام ضمنی اثرات):
- Nausea (متلی) and vomiting (قے) — more likely with rapid IV injection
- Dizziness (چکر آنا) and low blood pressure — particularly if IV is administered too quickly
- Headache (سردرد)
- Abdominal discomfort (پیٹ کی تکلیف)
- Pain or discomfort at the injection site (انجیکشن کی جگہ پر تکلیف)
Serious Side Effects (سنگین ضمنی اثرات — seek immediate medical help):
- Blood clot formation (خون کا لوتھڑا بننا) — signs include sudden leg pain or swelling, chest pain, shortness of breath (سانس لینے میں تکلیف), or sudden severe headache — requires immediate medical attention
- Seizures or convulsions (دورے پڑنا) — reported particularly at high IV doses — stop administration immediately
- Visual disturbances (نظر میں خرابی) — blurred vision or colour vision changes — discontinue and refer to eye specialist promptly
- Allergic reaction (الرجی) — rash, swelling of face or throat, difficulty breathing — seek emergency help immediately
Any serious adverse reaction must be reported to the administering healthcare professional immediately (فوری طور پر ڈاکٹر کو بتائیں).
Drug Interactions
Always inform your doctor about all medicines currently being administered (تمام ادویات کے بارے میں ڈاکٹر کو بتائیں).
| Medicine / Substance | Effect of Interaction |
|---|---|
| Combined hormonal contraceptives — OCP (مانع حمل گولیاں) | Significantly increases risk of blood clot formation — use with extreme caution |
| Factor IX complex / Anti-inhibitor coagulant concentrates | Increased risk of thrombosis (خون کا لوتھڑا) — avoid combination |
| Tretinoin (all-trans retinoic acid) | May increase risk of thrombotic complications |
| Anticoagulants — e.g. Warfarin (خون پتلا کرنے والی ادویات) | Tranexamic Acid opposes anticoagulant effects — requires careful monitoring |
| Penicillin and blood products | Do not mix in the same IV line — chemical incompatibility |
| Other haemostatic agents | Additive effect — increased clot risk — use only under medical supervision |
Storage Instructions
- Store below 25°C in a cool, dry place (ٹھنڈی اور خشک جگہ پر رکھیں)
- Keep away from direct sunlight and moisture (دھوپ اور نمی سے دور رکھیں)
- Do not freeze the ampoules (منجمد نہ کریں)
- Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں)
- Do not use after the expiry date printed on the ampoule or outer box (میعاد ختم ہونے کے بعد استعمال نہ کریں)
- Do not use if the solution appears discoloured or contains visible particles
- Discard any unused solution remaining in the ampoule after single use — do not store opened ampoules
Frequently Asked Questions (FAQs)
Q: What is Transamin Injection 250mg used for? Transamin Injection 250mg contains Tranexamic Acid — an antifibrinolytic medicine used to control serious excessive bleeding (ضرورت سے زیادہ خون بہنا) in hospital settings. It is used during and after surgery, in trauma emergencies, for haemoptysis in tuberculosis, abnormal uterine bleeding, and bleeding associated with blood disorders such as aplastic anaemia and leukaemia. It works by preventing blood clots from breaking down too early.
Q: What is the difference between Transamin Injection and Transamin Capsules? Both contain the same active ingredient — Tranexamic Acid — but are designed for different clinical situations. The capsules (250mg and 500mg) are taken orally for conditions such as heavy menstrual bleeding where slower, sustained action is appropriate. The injection delivers Tranexamic Acid directly into the bloodstream for immediate effect — making it the preferred choice in surgical, emergency, and critical care situations where rapid action and reliable absorption are essential.
Q: Can Transamin Injection be self-administered at home? No — Transamin Injection must only be administered by a trained healthcare professional (صرف تربیت یافتہ طبی عملہ انجیکشن لگا سکتا ہے) in a hospital, clinic, or appropriate medical setting. It requires careful IV administration at a controlled rate. Incorrect administration can cause serious side effects including low blood pressure and seizures.
Q: Why must the IV injection be given slowly? Rapid intravenous injection of Tranexamic Acid can cause a sudden drop in blood pressure (بلڈ پریشر کا اچانک گرنا), dizziness, and nausea. Guidelines recommend that IV Tranexamic Acid be administered at a rate not exceeding 1mL (50mg) per minute to minimise these risks. In most clinical settings it is given as a slow infusion diluted in IV fluids.
Q: What are the warning signs of a blood clot after receiving Transamin Injection? Signs of a dangerous blood clot (خون کا لوتھڑا) include sudden pain, redness or swelling in the leg, chest pain, shortness of breath, or sudden severe headache. Any of these symptoms after receiving Transamin Injection must be reported to the treating doctor or nursing staff immediately (فوری طور پر طبی عملے کو بتائیں).
⚕️ Medical Disclaimer: This product description is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Transamin Injection is a prescription medicine for hospital and clinical use only — it must be administered exclusively by or under the direct supervision of a qualified healthcare professional. This product is not for self-administration.
DRAP Registered | Prescription Only (Rx) | For IV / IM use by healthcare professionals only | Keep out of reach of children