Provas-N Tablet (Paracetamol 450mg / Orphenadrine Citrate 35mg)

Drug Class: Analgesic & Skeletal Muscle Relaxant Combination | Form: Oral Tablet | Prescription Status: Prescription Only (Rx) — DRAP Registered

What is Provas-N Tablet?

Provas-N Tablet is a combination medicine containing two active ingredients — Paracetamol 450mg and Orphenadrine Citrate 35mg. It is used for short-term relief of painful muscle conditions (پٹھوں کا درد اور کھنچاؤ). Paracetamol is a well-known pain reliever and fever reducer, while Orphenadrine is a muscle relaxant that relieves painful muscle spasms and stiffness. Together, they work on two levels at the same time — relaxing tense, knotted muscles while also relieving the pain caused by those spasms. This dual action makes Provas-N particularly effective for conditions where both muscle spasm and pain are present together. It is intended for short-term use only and must be taken as prescribed by your doctor.

What is Provas-N Tablet Used For?

Provas-N Tablet is approved for the short-term treatment of the following conditions:

• Muscle Sprains and Strains — overstretched or torn muscle fibres causing pain and spasm (پٹھوں کا کھنچاؤ یا موچ)
• Muscle Spasms — sudden, involuntary tightening of muscles causing sharp localised pain (پٹھوں کا اچانک کھچنا)
• Tension Headaches — headaches caused by tightness and spasm in the neck and shoulder muscles (سر درد جو گردن یا کندھوں کے پٹھوں کے کھچاؤ سے ہو)
• Acute Torticollis (Wry Neck) — sudden painful stiffness and twisting of the neck muscles (گردن کا اکڑ جانا — ٹیڑھی گردن)
• Back Pain from Muscle Spasm — lower or upper back pain caused by muscle tension and spasm (کمر درد جو پٹھوں کے کھچاؤ سے ہو)
• Post-Traumatic Muscle Pain — muscle pain and stiffness following an injury, fall, or physical strain
• Generalised Musculoskeletal Pain — pain in muscles, joints, and soft tissues from overuse or physical exertion

How Does Provas-N Tablet Work?

Provas-N Tablet combines two medicines that target muscle pain through different but complementary mechanisms:

Paracetamol (450mg) — Pain Reliever: Paracetamol works by blocking pain signals in the brain and nervous system. It raises the body's pain threshold — meaning a stronger stimulus is needed before pain is felt. It also helps reduce mild fever associated with inflammation. Paracetamol is well tolerated by the stomach and is one of the most widely used and trusted pain relievers in the world.

Orphenadrine Citrate (35mg) — Muscle Relaxant: Orphenadrine works on the central nervous system — specifically on the brain and spinal cord — to reduce the nerve signals that cause muscles to tighten and go into spasm. By calming these nerve signals, Orphenadrine allows tense, contracted muscles to relax, which relieves the stiffness, restricted movement, and sharp pain that muscle spasms cause. It also has a mild pain-relieving effect of its own, which adds to the overall effect of Paracetamol.

Together, these two ingredients provide faster and more complete relief from painful muscle conditions than either medicine would provide alone.

Dosage and Administration

⚠️ Always take this medicine exactly as your doctor prescribed. Do not take more than the recommended dose. Do not exceed the maximum daily dose of Paracetamol from all sources — check all other medicines you are taking for Paracetamol content. This medicine is for short-term use only.

• Swallow the tablet whole with a full glass of water
• Can be taken with or without food — take with food or milk if stomach upset occurs
• Do not take more than 6 tablets in any 24-hour period
• Do not use for more than a few days without medical review — this medicine is for short-term use only
• Do not take additional Paracetamol-containing medicines while using Provas-N — this includes many common cold and flu remedies
• Your doctor will advise on when it is appropriate to stop treatment

Active Ingredients

Who Should NOT Use Provas-N Tablet?

Do not take this medicine if you:

• Are allergic to Paracetamol, Orphenadrine, or any other ingredient in this tablet
• Have glaucoma — increased pressure inside the eye (آنکھ کا گلوکوما — آنکھ میں دباؤ کا بڑھنا)
• Have difficulty passing urine or an enlarged prostate (پیشاب میں رکاوٹ یا پروسٹیٹ کا بڑھنا)
• Have myasthenia gravis — a condition causing severe muscle weakness
• Have a blockage anywhere in the digestive system (stomach or intestinal obstruction)
• Have severe liver disease or a history of liver failure
• Are taking or have recently taken Monoamine Oxidase Inhibitors (MAOIs) — a type of antidepressant — within the last 14 days
• Are under 12 years of age — this medicine is not recommended for children

Tell your doctor before use if you have:

• Liver disease or regularly consume alcohol — Paracetamol can cause liver damage at high doses or in liver disease
• Kidney disease — dose adjustment may be needed
• Heart disease or irregular heartbeat (دل کی بیماری یا دھڑکن کی بے ترتیبی)
• A history of urinary problems
• Any history of drug or alcohol dependence
• If you are pregnant or breastfeeding — your doctor will assess safety before prescribing
• If you are elderly — Orphenadrine's anticholinergic effects may be stronger in older patients

Side Effects

Like all medicines, Provas-N Tablet can cause side effects. Not everyone will experience them. Many side effects are related to the Orphenadrine component and are dose-dependent.

Common Side Effects (relatively frequent):

• Dry mouth (منہ کا خشک ہونا) — most common side effect of Orphenadrine
• Dizziness or lightheadedness (چکر آنا)
• Drowsiness or mild sedation (غنودگی)
• Blurred vision (نظر کا دھندلا پن)
• Nausea or mild stomach upset
• Difficulty passing urine — particularly in men with prostate problems
• Mild constipation (قبض)
• Headache

Serious Side Effects (less common — seek medical help immediately):

• Severe allergic reaction — sudden rash, swelling of the face, lips, or throat, difficulty breathing
• Signs of liver damage — yellowing of skin or eyes (یرقان), dark urine, severe stomach pain — this can occur with Paracetamol overdose
• Rapid or irregular heartbeat (دل کی دھڑکن کا تیز یا بے ترتیب ہونا)
• Severe difficulty in passing urine — complete urinary retention
• Sudden eye pain or significant change in vision — may indicate acute glaucoma
• Confusion, agitation, or hallucinations — particularly in elderly patients
• Severe skin reaction — blistering, peeling, or widespread rash

If you notice any serious side effects, stop taking the medicine and go to the nearest hospital or emergency immediately.

Drug and Food Interactions

Tell your doctor about ALL medicines you are currently taking. Provas-N Tablet may interact with:

Always inform your doctor about all medicines, vitamins, herbal products, or supplements you are taking.

Storage Instructions

• Store below 25°C in a cool, dry place
• Keep away from direct sunlight and moisture
• Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں)
• Do not use after the expiry date printed on the pack
• Do not store in the bathroom or near a kitchen sink
• Keep tablets in their original packaging until use

Frequently Asked Questions

What is Provas-N Tablet used for?

Provas-N Tablet is used for short-term relief of painful muscle conditions including muscle spasms, sprains, strains, tension headaches, wry neck (torticollis), and back pain caused by muscle tightness. It combines a pain reliever (Paracetamol) and a muscle relaxant (Orphenadrine) to provide dual-action relief from both the pain and the underlying muscle spasm.

How is Provas-N different from regular Paracetamol tablets?

Regular Paracetamol only relieves pain and fever. Provas-N combines Paracetamol with Orphenadrine — a muscle relaxant — making it more effective specifically for pain that is caused by or associated with muscle spasms and tension. If your pain is related to muscle tightness, spasm, or stiffness, Provas-N addresses both the spasm and the pain at the same time.

Can Provas-N make me drowsy?

Yes, Orphenadrine can cause drowsiness and dizziness in some people. If you feel drowsy or dizzy after taking Provas-N, do not drive, operate heavy machinery, or perform any activity that requires full attention and alertness. This effect may be stronger if you also consume alcohol or take other sedative medicines.

Can I take Provas-N with other pain medicines?

Be very careful about taking any other medicines that also contain Paracetamol — including common cold and flu remedies, headache tablets, and many combination pain relievers. Taking too much Paracetamol from multiple sources can cause serious liver damage. Always check with your pharmacist before combining Provas-N with any other medicine.

How long can I take Provas-N Tablet?

Provas-N is intended for short-term use only — typically a few days for acute muscle conditions. It should not be used continuously for long periods without medical review. If your muscle pain or spasm does not improve within a few days, consult your doctor — you may need further investigation or a different treatment approach.

Is Provas-N safe during pregnancy?

Provas-N should only be used during pregnancy if your doctor clearly decides the benefit outweighs the risk. Orphenadrine in particular should be avoided during pregnancy unless absolutely necessary. Always tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding before taking this medicine.

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⚕️ Medical Disclaimer: This product description is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified doctor or pharmacist before starting, stopping, or changing any medication. This product is a prescription medicine — it must only be used under the supervision of a licensed healthcare professional.

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DRAP Registered | Prescription Required (Rx) | For use under medical supervision only