Drug Class: Antiplatelet Agent | NSAID | Form: Oral Tablet | Prescription Status: Prescription Only (Rx) — DRAP Registered
What is Loprin 150mg Tablet?
Loprin 150mg — also known as Loprin-DS — contains Aspirin 150mg, a well-established antiplatelet medicine that reduces the ability of platelets (tiny blood cells) to clump together and form dangerous clots inside blood vessels. At this low dose, Aspirin is used not as a painkiller but as a cardiovascular protective medicine — prescribed to reduce the risk of heart attacks (دل کا دورہ), strokes (فالج), and other serious blood clot-related events in patients with established heart disease or high cardiovascular risk. It is one of the most widely used and clinically proven medicines in cardiovascular care worldwide.
What is Loprin 150mg Used For?
- Prevention of heart attack — reducing the risk of first or repeat heart attack in high-risk patients (دل کے دورے کی روک تھام)
- Stroke prevention — reducing the risk of ischaemic stroke in patients with prior stroke or TIA (فالج کی روک تھام)
- Angina management — reducing cardiovascular events in patients with stable or unstable angina (سینے کا درد)
- Prevention of blood clots — after coronary artery procedures such as angioplasty or bypass surgery
- Peripheral artery disease — reducing clot risk in patients with blocked arteries in the legs
- Pre-eclampsia prevention — low-dose Aspirin is prescribed during pregnancy in high-risk women under strict medical supervision
How Does Loprin 150mg Work?
Aspirin permanently blocks an enzyme called COX-1 inside platelets, stopping the production of thromboxane A2 — a chemical that signals platelets to stick together and form clots. Because platelets cannot repair themselves, this antiplatelet effect lasts for the entire lifespan of the platelet — approximately 7 to 10 days. This means even a single daily dose of Loprin 150mg keeps platelets less sticky throughout the day, significantly reducing the risk of a clot forming inside a narrowed or damaged blood vessel — the main cause of most heart attacks and strokes.
Dosage and Administration
⚠️ Always take exactly as prescribed by your doctor. Do not stop taking Loprin without medical advice — stopping suddenly can increase the risk of a cardiovascular event.
| Indication | Usual Adult Dose | Frequency |
|---|---|---|
| Heart attack / Stroke prevention | 1 tablet (150mg) | Once daily |
| Angina | 1 tablet (150mg) | Once daily |
| Post-angioplasty / bypass | 1 tablet (150mg) | Once daily (as directed) |
| Pre-eclampsia prevention | 1 tablet (150mg) | Once daily at bedtime |
Critical Dosing Rules:
- Never stop Loprin suddenly without consulting your cardiologist — sudden discontinuation significantly raises the risk of a heart attack or stroke
- Taking with Ibuprofen or other NSAIDs regularly can block Aspirin's antiplatelet effect — inform your doctor
- If you miss a dose, take it as soon as you remember the same day — skip if it is the next day; never double the dose
How to Take:
- Swallow the tablet whole with a full glass of water
- Take with food or milk to protect the stomach
- Take at the same time each day — consistency is important for cardiovascular protection
- For pre-eclampsia use, bedtime dosing is recommended as directed by your obstetrician
Active Ingredients
| Ingredient | Strength per Tablet |
|---|---|
| Aspirin (Acetylsalicylic Acid) | 150mg |
Who Should NOT Take Loprin 150mg?
Do not take if you:
- Are allergic to Aspirin, Salicylates, or any NSAID
- Have experienced asthma, hives, or severe allergic reaction after taking any NSAID
- Have an active stomach ulcer or history of gastrointestinal bleeding
- Have severe kidney or liver failure
- Have haemophilia or any bleeding disorder
- Are taking Methotrexate at doses above 15mg per week
- Are in the third trimester of pregnancy (unless specifically prescribed)
- Are under 16 years of age — risk of Reye's syndrome
Always consult your doctor before taking Loprin if you have:
- History of stomach ulcers or digestive bleeding (معدے کا السر)
- Asthma — particularly aspirin-sensitive asthma
- Mild to moderate kidney or liver disease
- Gout — Aspirin at low doses can raise uric acid levels
- Are scheduled for surgery or a dental procedure — Aspirin increases bleeding risk
- Are taking blood thinners such as Warfarin or Clopidogrel
- Are in the first or second trimester of pregnancy
- Are breastfeeding
Side Effects
Common Side Effects:
- Stomach discomfort, nausea, or indigestion — reduced by taking with food
- Mild heartburn or bloating
- Prolonged bleeding from small cuts — expected antiplatelet effect
Serious Side Effects — Stop Taking and Seek Emergency Medical Attention Immediately:
- Gastrointestinal bleeding — black or tarry stools, vomiting blood, sudden severe stomach pain — even low-dose Aspirin carries this risk, especially with long-term use (طبی ہنگامی صورتحال)
- Severe allergic reaction — sudden widespread rash, swelling of face, lips, tongue or throat, difficulty breathing (یہ طبی ہنگامی صورتحال ہے)
- Aspirin-induced asthma — sudden severe wheezing or chest tightness after taking the tablet
- Haemorrhagic stroke — rare but serious; sudden severe headache, vision changes, or weakness on one side of the body
- Tinnitus (ringing in ears) or hearing loss — sign of Aspirin toxicity; consult doctor immediately
- Reye's syndrome — serious brain and liver condition in children and teenagers; never give Aspirin to anyone under 16 years
Drug Interactions
| Medicine / Substance | Possible Interaction |
|---|---|
| Warfarin / Clopidogrel / Heparin | Significantly increased bleeding risk — combination used only under strict cardiology supervision with regular INR monitoring |
| Ibuprofen and other NSAIDs | Ibuprofen blocks Aspirin's antiplatelet effect when taken regularly — take Aspirin at least 2 hours before Ibuprofen; inform your doctor |
| Methotrexate | Aspirin increases Methotrexate toxicity — avoid combination above 15mg/week Methotrexate |
| ACE Inhibitors / ARBs (e.g., Enalapril, Losartan) | High-dose Aspirin may reduce their blood pressure-lowering effect — low-dose 150mg generally acceptable |
| Diuretics (e.g., Furosemide) | Aspirin can reduce the effectiveness of diuretics in some patients |
| Antidiabetic medicines (e.g., Glibenclamide) | Aspirin may enhance blood sugar-lowering effect — monitor blood glucose |
| Corticosteroids (e.g., Prednisolone) | Increased gastrointestinal bleeding risk — use with caution |
| Alcohol (شراب) | Significantly increases gastrointestinal bleeding risk — avoid completely |
| Antacids | High-dose antacids can reduce Aspirin absorption and effectiveness |
Storage Instructions
- Store below 25°C in a cool, dry place
- Protect from moisture and direct sunlight
- Keep in original blister pack until use
- Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں)
- Do not use after the expiry date printed on the pack
Frequently Asked Questions (FAQs)
Q: Can I stop taking Loprin 150mg if I feel fine? Never stop Loprin without your doctor's advice — stopping suddenly significantly increases the risk of a heart attack or stroke, particularly in patients with stents or recent cardiac procedures.
Q: Can I take Loprin 150mg with Ibuprofen for pain? Occasional single doses of Ibuprofen are unlikely to cause a problem, but regular combined use blocks Aspirin's heart-protective antiplatelet effect — consult your doctor for a safer pain relief alternative.
Q: Is Loprin 150mg safe during pregnancy? Low-dose Aspirin is sometimes prescribed during pregnancy to prevent pre-eclampsia in high-risk women — but only under strict medical supervision. It must never be taken in the third trimester without a doctor's prescription.
Q: Should I stop Loprin before a surgery or dental procedure? Inform your surgeon or dentist that you are taking Loprin — stopping before a procedure is a decision only your cardiologist should make, as the risk of a cardiovascular event must be weighed against the bleeding risk.
Medical Disclaimer: This information is for general awareness only and does not replace advice from your doctor or pharmacist. Loprin 150mg is a prescription cardiovascular medicine — never start, stop, or change the dose without consulting your healthcare provider.