Drug Class: Anti-Epileptic Drug — AED | Synaptic Vesicle Protein SV2A Modulator | Form: Tablets (Oral) | Prescription Status: Prescription Only (Rx) — DRAP Registered
What is Lerace Tablets 750mg?
Lerace Tablets 750mg contain Levetiracetam — an anti-epileptic drug or AED (مرگی کی دوا) used to control various types of seizures (دورے) in adults and adolescents. Levetiracetam works by binding selectively to the SV2A synaptic vesicle protein in the brain — modulating neurotransmitter release and stabilising the abnormal electrical brain activity (دماغ میں غیر معمولی برقی سرگرمی) that causes and propagates seizures. The 750mg tablet is an intermediate higher strength — used when the standard 500mg dose has not achieved adequate seizure control and the dose needs to be increased, or when the treating neurologist determines this strength is clinically appropriate for a patient's seizure type and body weight. Like all Levetiracetam strengths, it can be used as monotherapy or in combination with other anti-epileptic medicines. It requires a valid prescription and must be managed under specialist neurological supervision.
What is Lerace 750mg Used For?
Lerace Tablets 750mg is indicated for the treatment of the following seizure types:
Partial-Onset Seizures — Focal Seizures (جزوی دورے) — seizures that begin in one specific area of the brain, with or without secondary generalisation — used in adults, adolescents, and children 6 years and older — as monotherapy in newly diagnosed patients (16 years and older) and as adjunctive therapy alongside other AEDs
Myoclonic Seizures (عضلاتی دورے) — sudden, brief, involuntary muscle jerks (اچانک پٹھوں کا جھٹکا) — used in patients 12 years and older with Juvenile Myoclonic Epilepsy as part of dose escalation when 500mg twice daily is insufficient
Primary Generalised Tonic-Clonic Seizures (عام دورے — پورے جسم میں) — convulsions involving stiffening followed by rhythmic jerking of the whole body (پورے جسم میں جھٹکے) — used in adults and adolescents 6 years and older with Idiopathic Generalised Epilepsy as dose is optimised
Adjunctive Therapy (اضافی علاج) — commonly used as add-on therapy alongside other anti-epileptic medicines in patients with difficult-to-control epilepsy where the lower doses have not achieved adequate seizure reduction
How Does Lerace 750mg Work?
Lerace contains Levetiracetam — a pyrrolidine derivative that works through a unique and highly selective mechanism compared to all other anti-epileptic drug classes.
Levetiracetam binds to the SV2A protein (Synaptic Vesicle Protein 2A — سائنیپٹک ویزیکل پروٹین 2A) located on the membrane of synaptic vesicles in nerve cells throughout the brain. Synaptic vesicles store and release neurotransmitters — the chemical signals that pass between nerve cells. By binding to SV2A, Levetiracetam modulates the controlled release of these neurotransmitters — reducing the excessive, repetitive, and disorganised electrical firing (غیر معمولی برقی سرگرمی) that underlies seizure activity.
Unlike older AEDs that act by broadly blocking sodium channels or enhancing inhibitory GABA activity, Levetiracetam's SV2A mechanism provides a more targeted approach to seizure suppression — with a distinct mechanism that complements other AEDs when used in combination therapy.
The 750mg strength delivers a higher therapeutic dose than 500mg — increasing SV2A receptor occupancy and providing stronger seizure control for patients who have not responded adequately to the standard dose. It is taken twice daily at 12-hour intervals to maintain consistent blood levels and sustained seizure protection throughout the day and night.
Dosage and Administration
Lerace Tablets must be taken exactly as prescribed by your neurologist. Never change your dose or stop treatment without medical advice (ڈاکٹر کے مشورے کے بغیر خوراک تبدیل نہ کریں یا دوا بند نہ کریں).
| Indication | Typical Use of 750mg Strength | Maximum Dose |
|---|---|---|
| Partial-onset seizures — adults ≥16 years | 750mg twice daily — after escalation from 500mg | Up to 1500mg twice daily |
| Myoclonic seizures — adults and adolescents ≥12 years | 750mg twice daily — during dose escalation phase | Up to 1500mg twice daily |
| Tonic-clonic seizures — adults and adolescents ≥12 years | 750mg twice daily — during dose optimisation | Up to 1500mg twice daily |
| Adjunctive therapy — difficult-to-control epilepsy | As directed by neurologist | Up to 1500mg twice daily |
Important Administration Instructions:
- Swallow tablets whole with a glass of water (پانی کے ساتھ پوری گولی نگلیں)
- Can be taken with or without food — take at the same times each day
- Take every 12 hours to maintain consistent blood levels throughout the day (12 گھنٹے کے وقفے سے لیں)
- Never stop Lerace suddenly — abrupt discontinuation can cause dangerous increases in seizure frequency or status epilepticus (اچانک بند نہ کریں — مسلسل دورے پڑ سکتے ہیں)
- Side effects such as drowsiness and irritability may be more noticeable at 750mg — inform your neurologist if they significantly affect daily life
- If you miss a dose (خوراک بھول جائیں) — take it as soon as you remember. If it is almost time for the next dose, skip the missed one. Never take a double dose.
- Carry a medical ID card or wear a medical alert bracelet stating your epilepsy diagnosis and medicines
Active Ingredients
| Ingredient | Role |
|---|---|
| Levetiracetam 750mg | Anti-epileptic — pyrrolidine derivative that binds to SV2A synaptic vesicle protein to modulate neurotransmitter release and reduce abnormal brain electrical activity causing seizures |
Also contains standard tablet excipients. Please check the product label or ask your pharmacist for full composition details.
Who Should NOT Use Lerace 750mg?
Do not use Lerace if you (استعمال نہ کریں اگر):
- Are allergic to Levetiracetam, other pyrrolidone derivatives, or any other ingredient in the tablet (الرجی ہو)
Tell your doctor before use if (ڈاکٹر کو بتائیں اگر):
- You have kidney problems (گردے کی بیماری) — dose reduction is required in renal impairment — this is especially important at higher doses such as 750mg
- You have a history of depression (ڈپریشن), suicidal thoughts (خودکشی کے خیالات), or other mental health conditions — psychiatric side effects may be more pronounced at higher doses
- You are pregnant (حاملہ) or planning pregnancy — your neurologist must carefully assess the risk-benefit balance for your individual situation
- You are breastfeeding (دودھ پلانے والی ماں) — Levetiracetam passes into breast milk — your doctor will advise
- You are elderly (بزرگ) — kidney function declines with age and dose reduction may be needed at this higher strength
- You have a history of behavioural problems or aggression (جارحانہ رویہ) — irritability and behavioural effects may be more noticeable at 750mg
Side Effects
Not everyone will experience side effects. At 750mg, some side effects — particularly drowsiness and mood-related effects — may be more noticeable than at the 500mg dose.
Common Side Effects (عام ضمنی اثرات):
- Drowsiness and fatigue (نیند اور تھکاوٹ) — may be more pronounced at 750mg — do not drive until you know how this dose affects you
- Headache (سردرد)
- Dizziness (چکر آنا)
- Nasopharyngitis — cold-like symptoms (نزلہ زکام جیسی علامات)
- Decreased appetite (بھوک کم لگنا)
- Irritability and mood changes (چڑچڑاپن اور مزاج میں تبدیلی) — monitor closely and report to your neurologist
Serious Side Effects (سنگین ضمنی اثرات — consult your doctor promptly):
- Psychiatric and behavioural effects (ذہنی اور رویے کی تبدیلیاں) — agitation, aggression, severe depression, hallucinations, or psychosis — risk may increase at higher doses — seek urgent medical attention
- Suicidal thoughts or self-harm (خودکشی کے خیالات) — AEDs as a class carry a small increased risk — seek immediate medical help
- Severe skin reactions (جلد کی شدید خرابی) — blistering or peeling rash — stop immediately and seek emergency help
- Worsening seizure frequency (دوروں کا بڑھنا) — contact your neurologist immediately
- Severe infection with fever — rarely associated with reduced white blood cell counts
Contact your doctor immediately if any serious side effect occurs (فوری طور پر ڈاکٹر سے رابطہ کریں).
Drug Interactions
Levetiracetam has significantly fewer drug interactions than most other anti-epileptic medicines. Always inform your doctor and pharmacist about all medicines you are currently taking (تمام ادویات کے بارے میں ڈاکٹر کو بتائیں).
| Medicine / Substance | Effect of Interaction |
|---|---|
| Other anti-epileptic medicines — e.g. Carbamazepine, Phenytoin | May increase CNS side effects such as drowsiness — monitor closely, particularly at higher Levetiracetam doses |
| Probenecid (گاؤٹ کی دوا) | Reduces Levetiracetam excretion — increases blood levels — more significant at higher doses |
| Methotrexate | Levetiracetam may increase Methotrexate levels — use with caution |
| Alcohol (شراب) | Significantly increases drowsiness and CNS depression — avoid completely, especially at higher doses |
| Sedatives and sleeping pills (نیند کی گولیاں) | Additive drowsiness — use with particular caution at 750mg |
| Oral contraceptives (مانع حمل گولیاں) | Levetiracetam does NOT reduce the effectiveness of hormonal contraceptives — unlike most older AEDs |
Storage Instructions
- Store below 25°C in a cool, dry place (ٹھنڈی اور خشک جگہ پر رکھیں)
- Keep away from direct sunlight and moisture (دھوپ اور نمی سے دور رکھیں)
- Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں)
- Do not use after the expiry date printed on the pack (میعاد ختم ہونے کے بعد استعمال نہ کریں)
- Store in the original packaging to protect from light
Frequently Asked Questions
What is Lerace 750mg used for?
Lerace 750mg contains Levetiracetam — an anti-epileptic medicine used to treat partial-onset seizures (جزوی دورے), myoclonic seizures (عضلاتی دورے), and primary generalised tonic-clonic seizures (پورے جسم میں دورے). The 750mg tablet is used when the 500mg dose has not achieved adequate seizure control — providing stronger SV2A receptor activation and more robust suppression of abnormal brain electrical activity. It is used as monotherapy or alongside other anti-epileptic medicines under neurological supervision.
How does Lerace 750mg differ from the 250mg and 500mg strengths?
All three strengths contain the same active ingredient — Levetiracetam — but at increasing doses. Treatment begins at 250mg and progresses through 500mg to 750mg as the neurologist optimises seizure control for each individual patient. The 750mg strength provides higher SV2A receptor occupancy and stronger seizure suppression — and is used when lower doses have been well tolerated but have not fully controlled seizures. Side effects such as drowsiness and irritability may be slightly more noticeable at 750mg.
Can I stop Lerace 750mg suddenly?
No — never stop Lerace abruptly (اچانک بند نہ کریں). Sudden discontinuation of any anti-epileptic medicine — including at the 750mg dose — can trigger a dangerous increase in seizure frequency or status epilepticus (مسلسل دورے) — a life-threatening emergency. Your neurologist will always taper the dose gradually when treatment needs to be changed or stopped. Never alter your dose independently.
Are mood and behavioural side effects more likely at 750mg?
Psychiatric and mood-related side effects — including irritability, agitation, and in rare cases more serious effects such as depression or aggression — can occur at any Levetiracetam dose, but may be more noticeable at 750mg compared to lower strengths. Patients, family members, and caregivers should monitor closely for any behavioural changes — particularly in the first weeks after a dose increase — and report them promptly to the neurologist (چڑچڑاپن یا رویے میں تبدیلی فوری ڈاکٹر کو بتائیں).
Does Lerace 750mg interact with other epilepsy medicines?
Levetiracetam has significantly fewer interactions with other medicines than most older anti-epileptic drugs — which is one of its key clinical advantages, particularly for patients on combination therapy. It does not induce liver enzymes and does not affect the blood levels of most other AEDs. However, combining any CNS-active medicines can increase drowsiness and dizziness — particularly at the 750mg dose. Always inform your neurologist and pharmacist of all medicines you are taking (تمام ادویات کے بارے میں ڈاکٹر کو بتائیں).
⚕️ Medical Disclaimer: This product description is for informational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Lerace is a prescription anti-epileptic medicine — always take it exactly as directed by your neurologist. Never stop this medicine suddenly. If you experience suicidal thoughts, severe behavioural changes, or a significant increase in seizures, seek immediate medical attention. Epilepsy management requires regular specialist review.
DRAP Registered | Prescription Only (Rx) | For oral use only | Keep out of reach of children