Drug Class: Nutritional Supplement — Inositol-Based PCOS Support | Form: Soft Gel Capsule | Pack Size: 30 Capsules | Prescription Status: Available Without Prescription (OTC) — Marketed by Galaxy Pharma
What is Inofolic Combi HP Capsule?
Inofolic Combi HP is a clinically formulated dietary supplement specifically designed for women with Polycystic Ovary Syndrome — particularly overweight and insulin-resistant PCOS patients where inositol deficiency and impaired inositol metabolism contribute significantly to hormonal dysregulation. It combines Myo-Inositol 550mg and D-Chiro-Inositol 13.8mg in a physiologically meaningful 40:1 ratio — the ratio naturally found in healthy human ovarian follicular fluid — alongside Alpha-Lactalbumin 14.1mg as a novel absorption-enhancing protein carrier and Folic Acid to support cellular health. The HP designation indicates a higher potency formulation specifically calibrated for overweight PCOS patients who have greater inositol resistance and require more targeted supplementation than standard inositol products. The soft gel capsule with soybean oil base improves bioavailability of the inositol components compared to powder formulations.
What is Inofolic Combi HP Used For?
- Polycystic ovary syndrome — comprehensive PCOS management addressing hormonal, metabolic, and reproductive aspects (پولی سسٹک اووری سنڈروم — ہارمونل توازن)
- Insulin resistance in PCOS — improving cellular insulin sensitivity and glucose metabolism (انسولین مزاحمت میں بہتری)
- Menstrual cycle regulation — restoring regular ovulatory menstrual cycles in PCOS (ماہواری کی بے قاعدگی میں بہتری)
- Fertility support in PCOS — improving oocyte quality and ovulation frequency (بیضہ دانی کی کارکردگی اور زرخیزی)
- Androgen excess management — reducing elevated testosterone and associated symptoms including hirsutism and acne (مردانہ ہارمون کی زیادتی میں کمی)
- Ovarian function support — supporting healthy follicular development and ovulation
- Weight management in PCOS — supporting metabolic parameters alongside dietary modification
- Preconception support — optimising hormonal and metabolic environment before conception in PCOS patients
How Does it Work?
Myo-Inositol 550mg and D-Chiro-Inositol 13.8mg are two naturally occurring forms of inositol — a carbocyclic sugar that functions as a second messenger in insulin signalling pathways. In healthy ovarian tissue the physiological ratio of Myo-Inositol to D-Chiro-Inositol is approximately 40:1 — Inofolic Combi HP precisely replicates this ratio. Myo-Inositol acts as a mediator of FSH signalling in ovarian follicles — improving follicular development, oocyte quality, and insulin receptor sensitivity in ovarian tissue. D-Chiro-Inositol acts as a mediator of insulin action in peripheral tissues — promoting glycogen synthesis and reducing androgen synthesis in theca cells, directly lowering elevated testosterone levels characteristic of PCOS. In overweight PCOS patients an enzyme that converts Myo-Inositol to D-Chiro-Inositol is overactive — paradoxically depleting ovarian Myo-Inositol while causing peripheral D-Chiro-Inositol excess. Supplementing both forms in the correct 40:1 ratio restores this balance. Alpha-Lactalbumin 14.1mg is a whey-derived protein that forms a molecular complex with inositol — significantly enhancing intestinal absorption and cellular uptake of both inositol forms, improving bioavailability beyond what either inositol form achieves alone. Folic Acid 0.20mcg supports DNA synthesis and cellular health throughout the reproductive cycle.
Dosage and Administration
⚠️ Take consistently at the same time each day for best results — inositol requires sustained supplementation to produce measurable hormonal and metabolic improvements. Results in menstrual regularity typically require minimum 3 months of consistent use. Not a replacement for medical PCOS management — always use alongside gynaecologist-supervised treatment. Contains soy-derived ingredients — avoid if soy allergy present.
| Indication | Usual Adult Female Dose | Frequency | Notes |
|---|---|---|---|
| PCOS management | 2 capsules | Once or twice daily | With meals for best absorption |
| Fertility support in PCOS | 2 capsules | Twice daily | Under gynaecologist supervision |
| Insulin resistance in PCOS | 2 capsules | Once daily | Alongside dietary modification |
| Preconception PCOS support | 2 capsules | Once daily | Start minimum 3 months before planned conception |
Active Ingredients
| Ingredient | Strength per Capsule | Primary Role |
|---|---|---|
| Myo-Inositol | 550mg | FSH signalling, oocyte quality, ovarian insulin sensitivity |
| D-Chiro-Inositol | 13.8mg | Peripheral insulin action, androgen reduction |
| Alpha-Lactalbumin | 14.1mg | Enhanced inositol absorption and bioavailability |
| Folic Acid | 0.20mcg | DNA synthesis and cellular health support |
Excipients:
Soybean oil, gelatin, glycerin, soy lecithin, iron oxides — patients with soy allergy should avoid this product.
Who Should NOT Take Inofolic Combi HP?
- Allergy to any ingredient — particularly soy allergy given soybean oil and soy lecithin content
- Allergy to milk proteins — Alpha-Lactalbumin is a whey-derived protein
- Pregnancy — while Myo-Inositol is generally considered safe in pregnancy, the complete HP formulation should only be continued during pregnancy under explicit obstetrician guidance
- Children under 18 years — formulated exclusively for adult women
- Men — this formulation is specifically designed for female hormonal physiology
- Women with medically confirmed normal inositol levels — supplementation without confirmed deficiency or PCOS diagnosis should be discussed with gynaecologist
- Severe kidney impairment — inositol clearance may be affected
Side Effects
Inofolic Combi HP is very well tolerated — inositol supplements have an excellent safety profile with side effects being uncommon and mild.
Common: Mild nausea particularly when starting supplementation — taking with food significantly reduces this (ابتدائی متلی — کھانے کے ساتھ لینے سے کم ہوتی ہے), mild stomach discomfort or loose stools at higher doses — usually resolves within first 1 to 2 weeks, mild headache during initial weeks of use — typically transient.
Serious — Seek medical attention if: Significant hypoglycaemia in diabetic women on antidiabetic medicines — Myo-Inositol improves insulin sensitivity and may lower blood glucose additively (بلڈ شوگر کا گرنا — فوری میٹھا کھائیں اور ڈاکٹر کو بتائیں), severe allergic reaction — sudden widespread rash, swelling of face or throat, difficulty breathing — particularly relevant given soy and milk protein content (فوری ہسپتال جائیں), significant worsening of any existing hormonal condition — consult gynaecologist promptly.
Drug Interactions
| Medicine | Interaction |
|---|---|
| Metformin | Both improve insulin sensitivity in PCOS — additive beneficial effect on insulin resistance; monitor blood glucose; combination commonly used together under gynaecologist guidance |
| Insulin / oral antidiabetics (sulphonylureas) | Myo-Inositol improves insulin sensitivity — additive blood glucose lowering; antidiabetic dose may need adjustment; monitor glucose closely |
| Clomiphene citrate (ovulation induction) | Myo-Inositol may improve ovarian response to Clomiphene — commonly used together for PCOS fertility under gynaecologist supervision |
| Oral contraceptive pills | OCPs deplete inositol levels — Inofolic may complement OCP use in PCOS management; consult gynaecologist |
| Antipsychotics (Olanzapine, Risperidone) | These medicines deplete inositol — supplementation may be beneficial but consult psychiatrist before combining |
| Lithium | Lithium inhibits inositol recycling — inositol supplementation may interact with Lithium's therapeutic mechanism; consult psychiatrist |
| Thyroid medicines (Levothyroxine) | PCOS commonly co-exists with thyroid disorders — no direct interaction but thyroid function should be monitored alongside PCOS management |
Storage:
Store below 25°C in a cool, dry place. Protect from moisture and direct sunlight. Keep in original packaging. Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں). Do not use after expiry date.
Frequently Asked Questions (FAQs)
Q: How long does Inofolic Combi HP take to show improvement in menstrual regularity and PCOS symptoms?
Inositol supplementation requires consistent long-term use — most women notice initial improvements in menstrual regularity within 3 months of consistent daily use. Meaningful improvements in hormonal parameters including testosterone reduction, AMH normalisation, and follicular development typically develop over 3 to 6 months. Ovulation restoration and fertility improvement may take 3 to 6 months of consistent supplementation. Do not judge effectiveness before completing at least one full 3-month supplementation cycle.
Q: Why does Inofolic Combi HP use the specific 40:1 ratio of Myo-Inositol to D-Chiro-Inositol?
The 40:1 ratio precisely replicates the physiological concentration found in healthy human ovarian follicular fluid. Clinical research has shown that this specific ratio provides optimal combined benefit — Myo-Inositol supporting follicular development and oocyte quality while D-Chiro-Inositol reduces androgen synthesis. Using too much D-Chiro-Inositol relative to Myo-Inositol actually worsens oocyte quality — making the precise 40:1 ratio clinically important rather than simply maximising either component individually.
Q: Can Inofolic Combi HP be taken alongside Metformin which my doctor has already prescribed for PCOS?
Yes — combining Myo-Inositol with Metformin is supported by clinical evidence and is a commonly used approach in PCOS management. Both improve insulin sensitivity through different mechanisms and their combined effect is generally additive. However blood glucose should be monitored more frequently when combining both as additive insulin sensitisation may lower blood glucose more than either alone — inform your gynaecologist that you are taking Inofolic alongside Metformin so they can monitor your response appropriately.
Medical Disclaimer: This information is for general awareness only and does not replace medical advice. Always consult your gynaecologist before starting any PCOS supplement, particularly if you are trying to conceive, have diabetes, or are taking prescription medicines.