Drug Class: High-Dose Therapeutic Vitamin D3 Supplement (Cholecalciferol) | Form: Softgel Capsule | Status: Prescription Only (Rx) — DRAP Registered | Pack: 1 Softgel Capsule (Single-Dose Box) | Manufacturer: Amarant Pharmaceuticals
What is Edwin-D Stat 200,000 IU?
Edwin-D Stat is a single high-dose therapeutic softgel capsule by Amarant Pharmaceuticals containing 200,000 IU of Cholecalciferol (Vitamin D3). It is specifically designed as a loading dose for rapid correction of severe Vitamin D deficiency under strict medical supervision. A single 200,000 IU dose rapidly replenishes depleted Vitamin D stores — restoring levels far faster than daily low-dose supplements. It is a prescription-only medicine and must never be taken without confirmed deficiency, doctor's prescription, and regular blood level monitoring.
What is Edwin-D Stat Used For?
- Rapid correction of severe Vitamin D deficiency (وٹامن ڈی کی شدید کمی)
- Treatment of osteomalacia — soft bones in adults (ہڈیوں کا نرم ہونا)
- Prevention and treatment of rickets in children under medical supervision (سوکھا روگ)
- Supporting bone strength and density correction (ہڈیوں کی مضبوطی)
- Rapid immune system restoration in severe deficiency states (قوت مدافعت)
- Supporting calcium and phosphate absorption correction
- Reducing muscle weakness and fatigue caused by severe Vitamin D deficiency (عضلاتی کمزوری)
- Post-surgical or post-fracture Vitamin D loading under orthopaedic supervision
How Does Edwin-D Stat Work?
Cholecalciferol (Vitamin D3) is absorbed in the small intestine and transported to the liver where it is converted to 25-hydroxyvitamin D — the storage form measured in blood tests. It is then converted in the kidneys to its active hormonal form — calcitriol — which regulates calcium and phosphate absorption in the gut. At 200,000 IU, Edwin-D Stat rapidly saturates Vitamin D storage in the body — correcting deficiency within days rather than the weeks required by standard daily supplementation. This makes it the preferred loading strategy for patients with confirmed severe deficiency requiring fast clinical correction of bone, immune, and muscular symptoms.
Dosage and Administration
| Indication | Dose | Frequency |
|---|---|---|
| Severe Vitamin D deficiency (loading) | 1 softgel (200,000 IU) | Single dose — or as prescribed |
| Periodic repletion under supervision | 1 softgel (200,000 IU) | Every 2–3 months as directed by doctor |
⚠️ This is a prescription-only therapeutic loading dose — not a daily supplement. Swallow the softgel whole with a meal containing fat — Vitamin D3 is fat-soluble and requires dietary fat for absorption. Never self-administer repeated doses without medical supervision and blood level monitoring between doses. Your doctor will determine the correct dosing interval based on your blood test results.
Active Ingredients
| Ingredient | Strength per Softgel |
|---|---|
| Cholecalciferol (Vitamin D3) | 200,000 IU (5000 mcg) |
Who Should NOT Take Edwin-D Stat?
- Patients with hypercalcaemia — already high blood calcium levels (خون میں کیلشیم کی زیادتی)
- Patients with hypervitaminosis D — already excess Vitamin D levels
- Patients with kidney stones — high Vitamin D dramatically increases calcium absorption (گردے کی پتھری)
- Patients with sarcoidosis or granulomatous diseases — dangerously heightened sensitivity to Vitamin D
- Patients with severe kidney disease — without nephrologist supervision
- Children — 200,000 IU is an adult therapeutic dose; paediatric dosing must be calculated by a doctor
- Pregnant or breastfeeding women — only under specialist medical supervision at this dose
- Patients with hypersensitivity to Vitamin D3 or any softgel excipient
- Never take without a confirmed blood test showing severe deficiency
Side Effects
Common (usually indicate excessive or repeated dosing):
- Mild nausea or loss of appetite
- Mild constipation or dry mouth
- Headache
Serious (Stop immediately and seek emergency medical attention if):
- Signs of hypercalcaemia or Vitamin D toxicity — excessive thirst, frequent urination, confusion, severe fatigue, muscle weakness, irregular heartbeat (یہ طبی ہنگامی صورتحال ہے)
- Kidney pain or significantly reduced urine output
- Severe nausea, vomiting, or abdominal pain following dose
- Sudden worsening of existing kidney condition
Drug Interactions
| Medicine / Substance | Possible Interaction |
|---|---|
| Thiazide diuretics (e.g., Hydrochlorothiazide) | Increase calcium reabsorption — combined with high-dose D3 significantly raises hypercalcaemia risk |
| Digoxin (heart medicine) | Hypercalcaemia from excess Vitamin D increases Digoxin toxicity risk — potentially fatal |
| Calcium supplements | Combined use increases risk of dangerously high blood calcium — monitor levels closely |
| Cholestyramine / Orlistat | Reduce fat-soluble vitamin absorption — Vitamin D3 absorption significantly reduced |
| Anticonvulsants (e.g., Phenytoin, Carbamazepine) | Accelerate Vitamin D breakdown — monitor levels and adjust dosing interval accordingly |
| Other Vitamin D supplements | Absolute contraindication to combine — serious toxicity risk with any additional D3 source |
Storage Instructions
- Store below 25°C in a cool, dry place
- Protect from direct sunlight and heat
- Do not freeze
- Keep in original single-dose box until use
- Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں)
- Do not use after the expiry date on the box
Frequently Asked Questions (FAQs)
Q: How is Edwin-D Stat different from regular Vitamin D supplements available OTC?
Regular OTC Vitamin D supplements provide 400–4000 IU for daily maintenance. Edwin-D Stat at 200,000 IU is a single therapeutic loading dose for rapid correction of severe confirmed deficiency — it is prescription-only and serves an entirely different clinical purpose from routine supplementation.
Q: How quickly will my Vitamin D levels improve after one Edwin-D Stat capsule?
Blood Vitamin D levels typically rise significantly within 1 to 2 weeks of a 200,000 IU loading dose. Your doctor will recheck levels after an appropriate interval — usually 6 to 8 weeks — to assess response and determine whether further doses or maintenance supplementation is required.
Q: How often can Edwin-D Stat be taken?
Dosing frequency is determined entirely by your doctor based on serial blood test results. Typical protocols involve a single loading dose followed by reassessment — repeated doses every 2 to 3 months may be prescribed for ongoing management. Never repeat the dose without medical review and blood monitoring.
Q: Can Edwin-D Stat be given to children?
The 200,000 IU adult loading dose must never be given to children without a paediatrician calculating a safe weight-appropriate dose. Children require significantly lower therapeutic doses — always seek specialist paediatric guidance before any high-dose Vitamin D administration in children.
Medical Disclaimer: This product description is for informational purposes only and does not replace professional medical advice. Edwin-D Stat 200,000 IU is a prescription-only therapeutic loading dose carrying a serious risk of Vitamin D toxicity and hypercalcaemia if taken without medical supervision and blood monitoring. Never self-administer this product. Always consult a qualified doctor before use and have Vitamin D and calcium blood levels checked regularly.