Drug Class: NSAID (Non-Steroidal Anti-Inflammatory Drug) | Form: Solution for Injection (IM/IV) | Prescription Status: Prescription Only (Rx) — DRAP Registered
What is Dyclo 75mg/3ml Injection? Dyclo Injection contains Diclofenac Sodium 75mg/3ml — an injectable NSAID that provides rapid and powerful relief of moderate to severe pain and inflammation where oral medicines are unsuitable, insufficient, or cannot be taken. The injectable route bypasses the gastrointestinal tract entirely — delivering therapeutic drug levels directly into the bloodstream within minutes for fast-onset pain relief. It is administered by a trained healthcare professional either as a deep intramuscular injection into the gluteal muscle or as a slow intravenous infusion in a clinical setting. Dyclo Injection is a short-term treatment only — typically used for acute pain episodes before transitioning to oral NSAID therapy once the patient can take medicines by mouth.
What is Dyclo 75mg/3ml Injection Used For?
- Acute moderate to severe musculoskeletal pain — injuries, fractures, and soft tissue trauma (شدید پٹھوں اور ہڈیوں کا درد)
- Post-operative pain — pain management following surgical procedures (آپریشن کے بعد شدید درد)
- Renal colic — severe pain from kidney stones (گردے کی پتھری کا شدید درد)
- Acute exacerbation of arthritis — sudden severe joint pain flare-ups (جوڑوں کے درد کا شدید دورہ)
- Acute back pain with severe muscle spasm — when oral medicines are insufficient (کمر کا شدید درد)
- Acute migraine with severe pain — when oral route is not feasible (شدید سر درد)
- Post-trauma pain — accident and injury-related severe pain management
How Does it Work? Diclofenac Sodium inhibits both COX-1 and COX-2 enzymes — blocking prostaglandin synthesis at sites of inflammation and in the central nervous system. Reduced prostaglandins decrease pain receptor sensitisation, reduce local tissue swelling, and lower fever through hypothalamic action. The injectable formulation achieves peak plasma concentrations within 20 to 30 minutes of intramuscular administration — significantly faster than oral tablets — making it particularly valuable for acute severe pain requiring rapid relief. Its combined central and peripheral analgesic action provides comprehensive pain control across a broad range of acute painful conditions.
Dosage and Administration
⚠️ Must be administered by a trained healthcare professional only — never self-inject. Deep IM injection into upper outer quadrant of gluteal muscle only — never inject into other sites. Use each ampoule once only — discard unused portion immediately. Maximum 2 days IM use — transition to oral therapy as soon as possible. Never combine with other injectable NSAIDs.
| Indication | Usual Adult Dose | Route | Maximum Daily Dose |
|---|---|---|---|
| Acute moderate to severe pain | 75mg | Deep IM injection | 150mg per day |
| Post-operative pain | 75mg | IM or slow IV infusion | 150mg per day |
| Renal colic | 75mg | Deep IM injection | 150mg per day |
| Acute arthritis flare | 75mg | Deep IM injection | 150mg per day |
Active Ingredients
| Ingredient | Strength |
|---|---|
| Diclofenac Sodium | 75mg per 3ml ampoule |
Who Should NOT Receive Dyclo Injection?
- Allergy to Diclofenac, Aspirin, or any other NSAID
- Active stomach ulcer or history of gastrointestinal bleeding
- Severe heart failure or established cardiovascular disease
- Severe kidney or liver impairment
- Third trimester of pregnancy — strictly contraindicated
- Aspirin-sensitive asthma or NSAID-induced bronchospasm
- Dehydrated patients — increased acute kidney injury risk
- Bleeding disorders or currently receiving anticoagulant therapy
- Children and adolescents under 18 years
- History of injection site reactions or local tissue damage from prior IM NSAIDs
Side Effects
Common: Injection site pain, redness, and mild swelling at IM injection site (انجیکشن کی جگہ پر درد اور سوجن), mild nausea, mild headache, mild dizziness — generally well tolerated with short-term use.
Serious — Report to treating doctor or seek emergency help immediately: Severe allergic reaction — sudden widespread rash, swelling of face or throat, difficulty breathing (فوری ہسپتال جائیں), gastrointestinal bleeding — dark tarry stools or vomiting blood (پیٹ سے خون — فوری مدد لیں), acute kidney injury — significantly reduced urination with ankle swelling after injection, severe injection site reactions — tissue necrosis or abscess at IM injection site (انجیکشن کی جگہ پر شدید ردعمل — فوری ڈاکٹر کو بتائیں), cardiovascular events — chest pain or sudden breathlessness, severe liver toxicity — yellowing of skin or eyes (یرقان), bronchospasm — sudden severe wheezing in aspirin-sensitive patients.
Drug Interactions
| Medicine | Interaction |
|---|---|
| Other NSAIDs or Aspirin above 75mg | Greatly increased gastrointestinal bleeding risk — never combine two NSAIDs |
| Warfarin / blood thinners | Significantly increased bleeding risk — INR monitoring essential |
| Antihypertensives (ACE inhibitors, ARBs, diuretics) | Diclofenac reduces their effectiveness and increases kidney stress |
| Methotrexate | Diclofenac increases Methotrexate toxicity — potentially fatal; avoid combination |
| Lithium | Diclofenac increases Lithium blood levels — toxicity risk |
| Cyclosporine / Tacrolimus | Increased kidney toxicity risk — avoid combination |
| Corticosteroids (Hydrocortisone injection) | Increased gastrointestinal ulceration and bleeding risk |
| SSRIs (Fluoxetine, Sertraline) | Increased gastrointestinal bleeding risk with NSAID combination |
| Digoxin | Diclofenac may increase Digoxin blood levels — monitor closely |
Storage: Store below 25°C in a cool, dry place. Protect from direct sunlight and freezing. Do not refrigerate. Keep ampoules in original packaging until use. Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں). Do not use after expiry date. Discard any unused solution immediately after opening — single use only.
FAQs
Q: How quickly does Dyclo Injection relieve pain after administration? Diclofenac IM injection reaches peak blood levels within 20 to 30 minutes — most patients experience meaningful pain relief within 30 minutes of administration, making it significantly faster than oral tablets which take 1 to 2 hours for comparable effect.
Q: Can Dyclo Injection be used for more than 2 days continuously? No — intramuscular Diclofenac is approved for maximum 2 days IM use due to injection site tissue damage risk with repeated injections at the same site. Transition to oral Diclofenac or another appropriate oral NSAID as soon as the patient can take medicines by mouth.
Q: Can Dyclo Injection be self-administered at home for severe pain? No — Diclofenac injection must only be administered by a trained healthcare professional in a clinical setting. Incorrect IM injection technique causes serious tissue damage, nerve injury, and injection site necrosis. Always seek medical care for severe pain requiring injectable treatment.
⚕️ Medical Disclaimer: This information is for general awareness only and does not replace medical advice. This medicine must only be administered by a qualified healthcare professional.