Drug Class: Antispasmodic Agent | Form: Tablets | Prescription Status: Prescription-Only (Rx) — DRAP Registered
What is Colofac 135mg?
Colofac 135mg is a prescription tablet containing Mebeverine Hydrochloride 135mg — an antispasmodic medicine that works directly on the muscles of the gut wall to relieve painful cramps and spasms (آنتوں کی اینٹھن اور درد کا علاج). It is primarily used to treat Irritable Bowel Syndrome (IBS) — a common condition causing recurring stomach pain, bloating, cramping, and unpredictable bowel habits. Unlike medicines that act on the whole body, Mebeverine works locally in the gut — relaxing overactive intestinal muscles without affecting normal bowel movement or causing sedation. A valid prescription from a doctor is required before use.
What is Colofac 135mg Used For?
- Irritable Bowel Syndrome — IBS (آنتوں کی تکلیف) — recurring stomach pain, cramping, bloating, diarrhoea, and constipation with no structural cause found
- Spastic Constipation — constipation caused by abnormal tightening of the bowel muscles rather than sluggish movement
- Chronic Irritable Colon — long-term bowel discomfort and unpredictable habits linked to gut muscle over-activity
- Mucous Colitis — gut inflammation and spasm producing mucus in the stool alongside abdominal pain
- Abdominal Pain and Cramping (پیٹ کا درد) — painful gut spasms associated with digestive disorders
- Bloating and Flatulence — uncomfortable gas and abdominal tightness related to bowel spasm
How Does Colofac 135mg Work?
Mebeverine Hydrochloride acts directly on the smooth muscle cells lining the wall of the intestine — reducing their sensitivity and preventing the excessive, painful contractions that cause IBS symptoms. It does this by blocking the movement of sodium into muscle cells, which reduces muscle over-activity and allows the gut to relax.
Importantly, Mebeverine is gut-selective — it works locally in the intestinal wall without affecting muscles elsewhere in the body and without entering the central nervous system. This means it relieves gut spasm effectively without causing drowsiness, dry mouth, or the side effects associated with older antispasmodic medicines. Normal bowel contractions needed for healthy digestion are preserved.
Dosage and Administration
| Patient | Dose | Frequency | Timing |
|---|---|---|---|
| Adults | 1 tablet (135mg) | 3 times daily | 20 minutes before meals |
| Elderly patients | Same adult dose | 3 times daily | 20 minutes before meals |
| Children under 10 | Not recommended | — | — |
Take each tablet 20 minutes before meals for best results. Swallow whole with water. Your doctor will advise the duration of treatment — do not stop or adjust the dose without consulting your doctor first.
Side Effects
Common: Colofac is generally very well tolerated. Side effects are uncommon at recommended doses.
Less Common: Mild allergic skin reactions such as rash, hives, or itching have been reported rarely.
Serious — stop and consult your doctor immediately if you notice: Severe allergic reaction including facial swelling, difficulty breathing, or widespread skin rash — though this is very rare with Mebeverine.
Important: This tablet contains lactose and sucrose. If your doctor has told you that you have an intolerance to certain sugars, consult your doctor before taking Colofac.
Who Should NOT Use Colofac 135mg?
- Known allergy to Mebeverine Hydrochloride or any other ingredient listed on the label
- Patients with rare hereditary conditions involving lactose or sucrose intolerance, or glucose-galactose malabsorption — this tablet contains both sugars
- Children under 10 years of age
- Pregnancy and breastfeeding — consult your doctor before use
Active Ingredients
| Ingredient | Role |
|---|---|
| Mebeverine Hydrochloride 135mg | Active ingredient — gut-selective antispasmodic |
| Lactose, Sucrose | Tablet base — note: contains sugars |
| Povidone, Acacia, Gelatin | Binders for tablet structure |
| Talc, Magnesium Stearate | Flow and lubrication excipients |
| Carnauba Wax | Tablet coating and polish |
Storage Instructions
- Store below 25°C in a cool, dry place away from direct sunlight and moisture
- Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں)
- Do not use after the expiry date printed on the pack
- Store in original packaging to protect from light
⚕️ Medical Disclaimer: This information is for general guidance only and does not replace your doctor's advice. Always take Colofac 135mg exactly as prescribed. Do not self-medicate with prescription medicines.
DRAP Registered | Prescription-Only (Rx) | Contains Lactose and Sucrose | For oral use only