Drug Class: Plant-Based Bone Health & Calcium Supplement | Form: Oral Tablet | Status: OTC Supplement — DRAP Registered | Pack: 30 Tablets | Manufacturer: Angelini
What is Calmize?
Calmize is a comprehensive bone health supplement by Angelini combining plant-derived Red Algae Calcium with Vitamin D3, Vitamin K2, Vitamin C, Iron, Vitamin B6, and Zinc. Unlike synthetic calcium sources, Red Algae Calcium is a natural, whole-food source rich in trace minerals that support a broader bone mineralisation environment. The combination of Vitamin D3 and K2 ensures calcium is absorbed efficiently and directed specifically into bone tissue — making Calmize a well-rounded formula for improving bone density and treating calcium deficiency.
What is Calmize Used For?
- Treatment and prevention of calcium deficiency (کیلشیم کی کمی)
- Supporting bone mineral density and treating osteoporosis (ہڈیوں کا بھربھرا پن)
- Reducing fracture risk in adults and elderly patients (ہڈی ٹوٹنے کا خطرہ)
- Supporting bone recovery after fractures or surgery
- Preventing and treating iron deficiency anaemia alongside bone support (خون کی کمی)
- Supporting immune function and collagen synthesis with Vitamin C (قوت مدافعت)
- Supporting bone health in postmenopausal women at risk of bone loss
- Nutritional support for patients with multiple deficiencies affecting bone health
How Does Calmize Work?
Red Algae Calcium at 1000mg provides a naturally derived, highly bioavailable calcium source — naturally accompanied by trace minerals including magnesium, boron, and silica that support bone mineralisation beyond what isolated calcium carbonate provides. Vitamin D3 at 400 IU maximises calcium absorption in the intestine — the essential cofactor without which calcium supplementation is largely ineffective. Vitamin K2 activates osteocalcin — directing calcium specifically into bone matrix — and activates Matrix GLA Protein that prevents calcium from depositing in arteries and soft tissues. Vitamin C at 50mg supports collagen synthesis — the structural protein framework within bone. Ferrous Sulphate at 27mg addresses iron deficiency commonly found alongside calcium deficiency. Vitamin B6 at 10mg reduces homocysteine — elevated levels of which are linked to increased fracture risk. Zinc at 30mg supports osteoblast activity — the cells responsible for building new bone tissue.
Dosage and Administration
| Indication | Dose | Frequency |
|---|---|---|
| Calcium deficiency & bone support | 1 tablet | Once daily with food |
| Osteoporosis management | 1 tablet | Once daily as prescribed |
| Post-fracture bone recovery | 1 tablet | Once daily as directed by doctor |
⚠️ Take with food for better calcium and iron absorption and to reduce stomach upset. Swallow whole with a full glass of water. Do not combine with other calcium, iron, or Vitamin D supplements without checking combined daily totals with your doctor. Always follow your doctor's prescribed duration.
Active Ingredients
| Ingredient | Strength per Tablet |
|---|---|
| Red Algae Calcium | 1000 mg |
| Ferrous Sulphate (Iron) | 27 mg |
| Zinc Sulphate (Zinc) | 30 mg |
| Vitamin C (Ascorbic Acid) | 50 mg |
| Vitamin B6 (Pyridoxine) | 10 mg |
| Vitamin D3 (Cholecalciferol) | 400 IU |
| Vitamin K2 (Menaquinone) | 25 mcg* |
Note: Some retail listings display 25mg — this is consistent with a labelling typographical error. Standard therapeutic Vitamin K2 doses range from 45–200mcg. The physiologically correct and intended value is 25mcg. Confirm with your pharmacist or the manufacturer Angelini if clarification is required.
Who Should NOT Take Calmize?
- Patients with hypercalcaemia — already high blood calcium levels (خون میں کیلشیم کی زیادتی)
- Patients with iron overload — haemochromatosis (فالتو آئرن کی بیماری) — contains Ferrous Sulphate 27mg
- Patients with kidney stones — calcium and Vitamin D supplementation may increase risk (گردے کی پتھری)
- Patients on Warfarin — Vitamin K2 directly affects blood clotting and will significantly alter INR
- Patients with severe kidney disease — without specialist supervision
- Patients with hypervitaminosis D — already excess Vitamin D levels
- Pregnant or breastfeeding women — consult doctor before use; contains Iron and Zinc at significant doses
- Children — consult paediatrician for age-appropriate dosing
Side Effects
Common:
- Dark or black stools — from Ferrous Sulphate iron content, generally harmless
- Mild nausea or stomach discomfort — take with food
- Mild constipation — increase fluid and fibre intake
- Mild bloating or gas
Serious (Stop and consult your doctor if):
- Signs of hypercalcaemia — excessive thirst, frequent urination, confusion, muscle weakness (یہ طبی توجہ کی ضرورت ہے)
- Signs of iron toxicity — severe abdominal pain, vomiting, extreme fatigue (یہ طبی ہنگامی صورتحال ہے)
- Unusual bruising or changes in bleeding — Vitamin K2 effect on coagulation
- Severe allergic reaction — rash, swelling, difficulty breathing (یہ طبی ہنگامی صورتحال ہے)
Drug Interactions
| Medicine / Substance | Possible Interaction |
|---|---|
| Warfarin (blood thinner) | Vitamin K2 directly reduces Warfarin effectiveness — serious INR disruption; avoid or monitor very closely |
| Levothyroxine (thyroid medicine) | Calcium, Iron, and Zinc reduce absorption — take thyroid medicine at least 4 hours apart |
| Tetracycline / Fluoroquinolone antibiotics | Calcium, Iron, and Zinc reduce antibiotic absorption — take 2–3 hours apart |
| Bisphosphonates (e.g., Alendronate) | Calcium reduces bisphosphonate absorption — take at least 2 hours apart |
| Thiazide diuretics | Increase calcium reabsorption — combined calcium supplementation raises hypercalcaemia risk |
| Other iron supplements | Risk of iron overload — never combine without doctor advice |
| Antacids | Reduce iron and calcium absorption — take Calmize at least 2 hours apart from antacids |
Storage Instructions
- Store below 25°C in a cool, dry place
- Protect from moisture and direct sunlight
- Keep in original packaging until use
- Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں)
- Do not use after the expiry date on the pack
Frequently Asked Question (FAQs)
Q: Why does Calmize use Red Algae Calcium instead of standard Calcium Carbonate?
Red Algae Calcium is a whole-food plant source naturally accompanied by trace minerals including magnesium, boron, and silica — nutrients that work alongside calcium for bone mineralisation. Standard Calcium Carbonate is an isolated mineral without these co-factors, making Red Algae Calcium a more comprehensive natural bone health ingredient.
Q: Why does Calmize contain Iron alongside Calcium?
Iron deficiency and calcium deficiency frequently coexist — particularly in women, elderly patients, and those with poor dietary intake. Calmize addresses both simultaneously. However, calcium and iron compete for absorption — take Calmize with food and avoid other iron sources at the same time.
Q: Can Calmize be taken alongside osteoporosis medicines like bisphosphonates?
Calcium and Vitamin D supplementation is routinely recommended alongside bisphosphonate therapy. Separate Calmize from bisphosphonate doses by at least 2 hours as calcium significantly reduces their absorption. Always inform your doctor about all supplements you are taking.
Q: Is Calmize suitable for postmenopausal women?
Yes, postmenopausal women face accelerated bone loss due to oestrogen decline. Calmize provides calcium, Vitamin D3, K2, and Zinc — key nutrients for maintaining bone density during and after menopause. Always consult your gynaecologist for a comprehensive bone health plan.
Medical Disclaimer: This product description is for informational purposes only and does not replace professional medical advice. Osteoporosis and bone loss require proper medical diagnosis and monitoring. Always consult a qualified doctor before starting any bone health supplement, particularly if you are on Warfarin, have kidney disease, iron overload conditions, or a history of kidney stones.