Drug Class: Broad-Spectrum Penicillin + Beta-Lactamase Inhibitor Combination | Form: Tablet | Prescription Status: Prescription-Only (Rx) — DRAP Registered
What is Calamox 375mg?
Calamox 375mg is a prescription combination antibiotic tablet containing Amoxicillin 250mg and Clavulanic Acid 125mg, used to treat a wide range of bacterial infections (بیکٹیریل انفیکشن) of the respiratory tract, ears, sinuses, skin, urinary tract, and teeth. It is the standard-strength formulation in the Calamox range, suitable for mild to moderate bacterial infections in adults and children. Amoxicillin kills susceptible bacteria by disrupting their cell wall formation. Clavulanic Acid protects Amoxicillin from being destroyed by beta-lactamase enzymes produced by resistant bacteria, broadening its effectiveness against a wider range of organisms.
What is Calamox 375mg Used For?
Respiratory Tract Infections: Treats bronchitis, pneumonia, and bacterial chest infections caused by susceptible organisms. Ear, Nose, and Throat Infections: Manages sinusitis, tonsillitis, and otitis media caused by bacteria. Skin and Soft Tissue Infections: Treats cellulitis and skin abscesses caused by susceptible bacteria. Urinary Tract Infections: Manages cystitis and other UTIs caused by susceptible gram-negative organisms. Dental Infections: Treats bacterial infections of the teeth and gums.
How Does Calamox 375mg Work?
Amoxicillin binds to penicillin-binding proteins in the bacterial cell wall, preventing bacteria from completing cell wall synthesis. Without an intact cell wall, bacteria cannot survive or multiply. Clavulanic Acid inhibits beta-lactamase enzymes that resistant bacteria produce to destroy Amoxicillin, protecting it from degradation and allowing it to work effectively against a broader range of resistant bacterial strains.
Dosage and Administration
| Situation | Dose | Frequency |
|---|---|---|
| Mild to moderate infections | 1 tablet (375mg) | Three times daily |
| As prescribed | Follow doctor's instructions | Complete the full course |
Take at the start of a meal to reduce stomach upset. Swallow whole with a full glass of water. Always complete the full prescribed course.
Active Ingredients
| Ingredient | Role |
|---|---|
| Amoxicillin 250mg | Penicillin antibiotic — kills bacteria by disrupting cell wall synthesis |
| Clavulanic Acid 125mg | Beta-lactamase inhibitor — protects Amoxicillin from bacterial enzyme degradation |
Who Should NOT Use Calamox 375mg?
Do not use if you have a known allergy to Amoxicillin, Clavulanic Acid, or any penicillin or cephalosporin antibiotic. Tell your doctor if you have liver disease, kidney problems, or a history of jaundice related to previous use of Amoxicillin-Clavulanic Acid. Inform your doctor if you are pregnant or breastfeeding.
Side Effects
Common: Nausea, diarrhea, stomach upset, skin rash, headache. Serious (seek immediate help): Severe allergic reaction including facial swelling or difficulty breathing. Signs of liver problems including yellowing of skin or eyes. Severe diarrhea with blood or mucus indicating possible Clostridioides difficile infection.
Storage
Store below 25°C in a dry place away from direct sunlight and moisture. Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں). Do not use after the expiry date.
Frequently Asked Questions
How is Calamox 375mg different from Calamox 1g?
Calamox 375mg contains a lower dose of Amoxicillin (250mg) and is prescribed for mild to moderate infections. Calamox 1g contains Amoxicillin 875mg and is reserved for more severe or resistant infections requiring stronger antibiotic cover. Your doctor will prescribe the most appropriate strength based on the type and severity of your infection.
Should I take Calamox 375mg with food?
Yes. Always take Calamox 375mg at the start of a meal. Food reduces the risk of nausea and stomach discomfort and also improves the absorption of Clavulanic Acid into the bloodstream.
Medical Disclaimer: This description is for informational purposes only and does not replace professional medical advice. Always follow your doctor's prescription and consult your pharmacist for personal guidance.
DRAP Registered | Prescription Required (Rx) | Broad-Spectrum Antibiotic | Amoxicillin + Clavulanic Acid