{"product_id":"cidine-tablets-1mg","title":"Cidine 1mg Tablet (Cinitapride Hydrogen Tartrate 1mg)","description":"\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eDrug Class:\u003c\/strong\u003e Prokinetic Agent \/ Serotonin Agonist + Dopamine Antagonist | \u003cstrong\u003eForm:\u003c\/strong\u003e Oral Tablet | \u003cstrong\u003ePrescription Status:\u003c\/strong\u003e Prescription Only (Rx) — DRAP Registered\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eWhat is Cidine 1mg Tablet?\u003c\/strong\u003e Cidine 1mg contains Cinitapride Hydrogen Tartrate — a prokinetic agent with a unique dual mechanism that simultaneously stimulates serotonin receptors and blocks dopamine receptors in the gastrointestinal tract to enhance stomach and upper gut motility. Unlike Metoclopramide which relies solely on dopamine blockade, Cinitapride's additional serotonin agonist activity produces a more physiologically coordinated enhancement of gastric emptying and oesophageal sphincter tone. It is specifically designed to be taken 15 minutes before each main meal — ensuring peak prokinetic activity coincides precisely with food entering the stomach for maximum therapeutic benefit. Cidine 1mg is prescribed for functional digestive disorders where slow gastric emptying and poor oesophageal sphincter function cause persistent symptoms affecting quality of life.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eWhat is Cidine 1mg Used For?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eGastroesophageal reflux disease — GERD with slow gastric emptying component (سینے کی جلن اور تیزابیت)\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eNon-ulcer dyspepsia — functional bloating, early fullness, and upper abdominal discomfort (بدہضمی اور پیٹ پھولنا)\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eGastroparesis — significantly delayed stomach emptying causing nausea and fullness (معدے کا کھانا دیر سے خالی کرنا)\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eGastritis-related motility symptoms — nausea and heaviness from stomach inflammation (معدے کی سوزش میں متلی)\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eOesophageal motility disorders — impaired oesophageal peristalsis causing swallowing discomfort\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003ePost-meal heaviness and slow digestion — persistent discomfort after eating (کھانے کے بعد بھاری پن)\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eHow Does it Work?\u003c\/strong\u003e Cinitapride works through two complementary mechanisms simultaneously. It acts as a serotonin 5-HT4 receptor agonist — stimulating serotonin-mediated enhancement of coordinated gastric and intestinal muscle contractions that accelerate stomach emptying and improve upper gut motility. Simultaneously it blocks dopamine D2 receptors in the gut — removing dopamine's inhibitory effect on gastric smooth muscle contractions. Together these two actions produce more comprehensive and physiologically coordinated prokinetic effect than dopamine blockade alone. Additionally Cinitapride increases lower oesophageal sphincter tone — reducing the reflux of acid from the stomach into the oesophagus, directly addressing the motility component of GERD.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eDosage and Administration\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e⚠️ Take exactly 15 minutes before each main meal for maximum effectiveness — timing with food is clinically important. Never exceed prescribed dose. Long-term use requires regular medical review due to potential prolactin-related hormonal effects.\u003c\/p\u003e\n\u003cdiv class=\"overflow-x-auto w-full px-2 mb-6\"\u003e\n\u003ctable class=\"min-w-full border-collapse text-sm leading-[1.7] whitespace-normal\"\u003e\n\u003cthead class=\"text-left\"\u003e\n\u003ctr\u003e\n\u003cth scope=\"col\" class=\"text-text-100 border-b-0.5 border-border-300\/60 py-2 pr-4 align-top font-bold\"\u003eIndication\u003c\/th\u003e\n\u003cth scope=\"col\" class=\"text-text-100 border-b-0.5 border-border-300\/60 py-2 pr-4 align-top font-bold\"\u003eUsual Adult Dose\u003c\/th\u003e\n\u003cth scope=\"col\" class=\"text-text-100 border-b-0.5 border-border-300\/60 py-2 pr-4 align-top font-bold\"\u003eFrequency\u003c\/th\u003e\n\u003cth scope=\"col\" class=\"text-text-100 border-b-0.5 border-border-300\/60 py-2 pr-4 align-top font-bold\"\u003eTiming\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eGERD \/ Functional dyspepsia\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e1mg\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eThree times daily\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e15 minutes before each main meal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eGastroparesis\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e1mg\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eThree times daily\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e15 minutes before each main meal\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eGastritis-related motility disorder\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e1mg\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eThree times daily\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e15 minutes before meals as prescribed\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eActive Ingredients\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"overflow-x-auto w-full px-2 mb-6\"\u003e\n\u003ctable class=\"min-w-full border-collapse text-sm leading-[1.7] whitespace-normal\"\u003e\n\u003cthead class=\"text-left\"\u003e\n\u003ctr\u003e\n\u003cth scope=\"col\" class=\"text-text-100 border-b-0.5 border-border-300\/60 py-2 pr-4 align-top font-bold\"\u003eIngredient\u003c\/th\u003e\n\u003cth scope=\"col\" class=\"text-text-100 border-b-0.5 border-border-300\/60 py-2 pr-4 align-top font-bold\"\u003eStrength\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eCinitapride Hydrogen Tartrate\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e1mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eWho Should NOT Take Cidine 1mg?\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eAllergy to Cinitapride or any component of the tablet\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eGastrointestinal obstruction, perforation, or bleeding — prokinetics strictly contraindicated\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003ePhaeochromocytoma — adrenal gland tumour\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eProlactin-dependent tumours — breast cancer or pituitary tumours\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eEpilepsy or history of seizures — dopamine blockade lowers seizure threshold\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eParkinson's disease — dopamine antagonism directly worsens symptoms\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003ePregnancy and breastfeeding — consult doctor before use\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eChildren under 18 years — safety not established\u003c\/li\u003e\n\u003cli class=\"whitespace-normal break-words pl-2\"\u003eSevere liver or kidney impairment\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSide Effects\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eCommon:\u003c\/em\u003e Mild drowsiness, mild headache, mild diarrhoea or loose stools, mild stomach cramping — generally well tolerated with the serotonin agonist mechanism providing better tolerability than pure dopamine antagonists.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003eSerious — Stop and seek medical attention immediately:\u003c\/em\u003e Tardive dyskinesia — involuntary repetitive facial or body movements with prolonged use (غیر ارادی حرکات — فوری ڈاکٹر کو دکھائیں), elevated prolactin levels causing breast tenderness, milk production in non-breastfeeding women or men, or irregular menstrual periods (ماہواری کی بے قاعدگی — ڈاکٹر کو بتائیں), acute dystonia — sudden painful involuntary muscle contractions particularly in neck and face (فوری مدد لیں), severe allergic reaction with swelling of face or throat and difficulty breathing (فوری ہسپتال جائیں), worsening of Parkinson's symptoms if used in parkinsonian patients — avoid entirely.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eDrug Interactions\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv class=\"overflow-x-auto w-full px-2 mb-6\"\u003e\n\u003ctable class=\"min-w-full border-collapse text-sm leading-[1.7] whitespace-normal\"\u003e\n\u003cthead class=\"text-left\"\u003e\n\u003ctr\u003e\n\u003cth scope=\"col\" class=\"text-text-100 border-b-0.5 border-border-300\/60 py-2 pr-4 align-top font-bold\"\u003eMedicine\u003c\/th\u003e\n\u003cth scope=\"col\" class=\"text-text-100 border-b-0.5 border-border-300\/60 py-2 pr-4 align-top font-bold\"\u003eInteraction\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eAnticholinergic medicines (Hyoscine, Procyclidine)\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eDirectly oppose Cinitapride's prokinetic action — significantly reduced effectiveness\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eOther dopamine antagonists (Metoclopramide, Levosulpiride)\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eAdditive dopamine blockade — increased movement disorder and hormonal side effect risk\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eLevodopa \/ Dopamine agonists\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eCinitapride directly opposes their therapeutic effect — avoid combination in Parkinson's patients\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eSerotonergic medicines (SSRIs, Tramadol)\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eAdditive serotonin activity — increased serotonin syndrome risk with combination\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eCNS depressants \/ sedatives\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eAdditive drowsiness and sedation — use with caution\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eDigoxin\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eAccelerated gastric emptying may alter Digoxin absorption rate — monitor levels\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eAnticoagulants (Warfarin)\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eChanges in gastric emptying rate may affect Warfarin absorption — INR monitoring recommended\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eAlcohol (شراب)\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eMay worsen nausea and gastrointestinal discomfort — avoid during treatment\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eStorage:\u003c\/strong\u003e Store below 25°C in a cool, dry place. Protect from moisture and direct sunlight. Keep out of reach of children (بچوں کی پہنچ سے دور رکھیں). Do not use after expiry date.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eFAQs\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eQ: Why must Cidine 1mg be taken exactly 15 minutes before meals rather than with food?\u003c\/strong\u003e Cinitapride needs to be absorbed and reach peak concentration in gut tissue before food arrives in the stomach — taking it 15 minutes before eating ensures maximum prokinetic activity precisely when gastric emptying and oesophageal sphincter tone are most critically needed, providing significantly better symptom control than taking with or after food.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eQ: How is Cinitapride in Cidine different from Metoclopramide for digestive problems?\u003c\/strong\u003e Cinitapride combines serotonin 5-HT4 agonism with dopamine D2 blockade — producing more physiologically coordinated gastric motility enhancement than Metoclopramide's pure dopamine blockade alone. This dual mechanism generally provides better symptom control with potentially improved tolerability for functional digestive disorders.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eQ: Can Cidine 1mg be taken long-term for chronic GERD or dyspepsia?\u003c\/strong\u003e Long-term use requires regular medical reassessment — prolonged dopamine blockade carries risk of elevated prolactin levels and rare movement disorders. Your doctor should periodically evaluate whether continued prokinetic therapy remains necessary and whether the benefits continue to outweigh any emerging risks.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cem\u003e\u003cstrong\u003eMedical Disclaimer:\u003c\/strong\u003e This information is for general awareness only and does not replace medical advice. Always consult a qualified doctor or pharmacist before taking any prescription medicine.\u003c\/em\u003e\u003c\/p\u003e","brand":"Upper Lines Pharmacy","offers":[{"title":"Default Title","offer_id":50980366713147,"sku":"ULP-0513-1mg","price":521.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0950\/5885\/4203\/files\/CidineTablets1mg.webp?v=1771556656","url":"https:\/\/upperlines.com.pk\/products\/cidine-tablets-1mg","provider":"Upper Lines Pharmacy","version":"1.0","type":"link"}